Domenico De Santis

Dr. Domenico De Santis

Sapienza University of Rome, Rome, Lazio, Italy
orcid

Research Focus & Metrics

Academic Career Length

14Years (2013-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 August 2017 in American Journal of Roentgenology
Verified
Journal Article
Closed access
MEMarwen Eid
Marwen Eid
CCCarlo N. De Cecco
Carlo N. De Cecco
JNJr. John W. Nance
Jr. John W. Nance
Damiano CarusoDamiano Caruso
Damiano Caruso
MAMoritz H. Albrecht
Moritz H. Albrecht
USU. Joseph Schoepf
U. Joseph Schoepf
OBJECTIVE. The purpose of this article is to present an overview of cinematic rendering, illustrating its potential advantages and applications. CONCLUSION. Volume-rendered reconstruction, obtaining 3D visualization from original CT datasets, is increasingly used by physicians and medical educators in various clinical and educational scenarios. Cinematic rendering is a novel 3D rendering algorithm that simulates the propagation and interaction of light rays as they pass through the volumetric data, showing a more photorealistic representation of 3D images than achieved with standard volume rendering.

6 December 2018 in European Radiology
Verified
Journal Article
Closed access
PDF file
PDPhilipp L. von Knebel Doeberitz
Philipp L. von Knebel Doeberitz
CCCarlo N. De Cecco
Carlo N. De Cecco
USU. Joseph Schoepf
U. Joseph Schoepf
TDTaylor M. Duguay
Taylor M. Duguay
MAMoritz H. Albrecht
Moritz H. Albrecht
CTChristian Tesche
Christian Tesche

16 June 2023 in La radiologia medica
Verified
Journal Article
Open access
PDF file
TPTiziano Polidori
Tiziano Polidori
DSDomenico De Santis
Domenico De Santis
CRCarlotta Rucci
Carlotta Rucci
GTGiuseppe Tremamunno
Giuseppe Tremamunno
GPGiulia Piccinni
Giulia Piccinni
Damiano CarusoDamiano Caruso
Damiano Caruso
Radiomics is a new emerging field that includes extraction of metrics and quantification of so-called radiomic features from medical images. The growing importance of radiomics applied to oncology in improving diagnosis, cancer staging and grading, and improved personalized treatment, has been well established; yet, this new analysis technique has still few applications in cardiovascular imaging. Several studies have shown promising results describing how radiomics principles could improve the diagnostic accuracy of coronary computed tomography angiography (CCTA) and magnetic resonance imaging (MRI) in diagnosis, risk stratification, and follow-up of patients with coronary heart disease (CAD), ischemic heart disease (IHD), hypertrophic cardiomyopathy (HCM), hypertensive heart disease (HHD), and many other cardiovascular diseases. Such quantitative approach could be useful to overcome the main limitations of CCTA and MRI in the evaluation of cardiovascular diseases, such as readers’ subjectiveness and lack of repeatability. Moreover, this new discipline could potentially overcome some technical problems, namely the need of contrast administration or invasive examinations. Despite such advantages, radiomics is still not applied in clinical routine, due to lack of standardized parameters acquisition, inconsistent radiomic methods, lack of external validation, and different knowledge and experience among the readers. The purpose of this manuscript is to provide a recent update on the status of radiomics clinical applications in cardiovascular imaging.

19 February 2018 in European Radiology
Verified
Journal Article
Closed access
PDF file
CCCarlo N. De Cecco
Carlo N. De Cecco
Damiano CarusoDamiano Caruso
Damiano Caruso
USU. Joseph Schoepf
U. Joseph Schoepf
DSDomenico De Santis
Domenico De Santis
GMGiuseppe Muscogiuri
Giuseppe Muscogiuri
AHAndrew D. Hardie
Andrew D. Hardie

27 February 2023 in La radiologia medica
Verified
Journal Article
Open access
PDF file
DSDomenico De Santis
Domenico De Santis
TPTiziano Polidori
Tiziano Polidori
GTGiuseppe Tremamunno
Giuseppe Tremamunno
CRCarlotta Rucci
Carlotta Rucci
GPGiulia Piccinni
Giulia Piccinni
Damiano CarusoDamiano Caruso
Damiano Caruso
Purpose: To perform a comprehensive intraindividual objective and subjective image quality evaluation of coronary CT angiography (CCTA) reconstructed with deep learning image reconstruction (DLIR) and to assess correlation with routinely applied hybrid iterative reconstruction algorithm (ASiR-V). Material and methods: Fifty-one patients (29 males) undergoing clinically indicated CCTA from April to December 2021 were prospectively enrolled. Fourteen datasets were reconstructed for each patient: three DLIR strength levels (DLIR_L, DLIR_M, and DLIR_H), ASiR-V from 10% to 100% in 10%-increment, and filtered back-projection (FBP). Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) determined objective image quality. Subjective image quality was assessed with a 4-point Likert scale. Concordance between reconstruction algorithms was assessed by Pearson correlation coefficient. Results: DLIR algorithm did not impact vascular attenuation (P ≥ 0.374). DLIR_H showed the lowest noise, comparable with ASiR-V 100% (P = 1) and significantly lower than other reconstructions (P ≤ 0.021). DLIR_H achieved the highest objective quality, with SNR and CNR comparable to ASiR-V 100% (P = 0.139 and 0.075, respectively). DLIR_M obtained comparable objective image quality with ASiR-V 80% and 90% (P ≥ 0.281), while achieved the highest subjective image quality (4, IQR: 4–4; P ≤ 0.001). DLIR and ASiR-V datasets returned a very strong correlation in the assessment of CAD (r = 0.874, P = 0.001). Conclusion: DLIR_M significantly improves CCTA image quality and has very strong correlation with routinely applied ASiR-V 50% dataset in the diagnosis of CAD.

7 September 2022 in La radiologia medica
Verified
Journal Article
Open access
PDF file
MZMarta Zerunian
Marta Zerunian
Francesco PucciarelliFrancesco Pucciarelli
Francesco Pucciarelli
Damiano CarusoDamiano Caruso
Damiano Caruso
MPMichela Polici
Michela Polici
BMBenedetta Masci
Benedetta Masci
ALAndrea Laghi
Andrea Laghi
Purpose: To compare liver MRI with AIR Recon Deep Learning™(ARDL) algorithm applied and turned-off (NON-DL) with conventional high-resolution acquisition (NAÏVE) sequences, in terms of quantitative and qualitative image analysis and scanning time. Material and methods: This prospective study included fifty consecutive volunteers (31 female, mean age 55.5 ± 20 years) from September to November 2021. 1.5 T MRI was performed and included three sets of images: axial single-shot fast spin-echo (SSFSE) T2 images, diffusion-weighted images(DWI) and apparent diffusion coefficient(ADC) maps acquired with both ARDL and NAÏVE protocol; the NON-DL images, were also assessed. Two radiologists in consensus drew fixed regions of interest in liver parenchyma to calculate signal-to-noise-ratio (SNR) and contrast to-noise-ratio (CNR). Subjective image quality was assessed by two other radiologists independently with a five-point Likert scale. Acquisition time was recorded. Results: SSFSE T2 objective analysis showed higher SNR and CNR for ARDL vs NAÏVE, ARDL vs NON-DL(all P < 0.013). Regarding DWI, no differences were found for SNR with ARDL vs NAÏVE and, ARDL vs NON-DL (all P > 0.2517).CNR was higher for ARDL vs NON-DL(P = 0.0170), whereas no differences were found between ARDL and NAÏVE(P = 1). No differences were observed for all three comparisons, in terms of SNR and CNR, for ADC maps (all P > 0.32). Qualitative analysis for all sequences showed better overall image quality for ARDL with lower truncation artifacts, higher sharpness and contrast (all P < 0.0070) with excellent inter-rater agreement (k ≥ 0.8143). Acquisition time was lower in ARDL sequences compared to NAÏVE (SSFSE T2 = 19.08 ± 2.5 s vs. 24.1 ± 2 s and DWI = 207.3 ± 54 s vs. 513.6 ± 98.6 s, all P < 0.0001). Conclusion: ARDL applied on upper abdomen showed overall better image quality and reduced scanning time compared with NAÏVE protocol.