Background: Hospital-acquired infections (HAI) contribute to the emotional stress and functional disorders of the patient and in some cases, can lead to a state of disability that reduces quality of life. Often, HAI are one of the factors that lead to death. The purpose of this study was to analyze the cases of HAI identified in public hospitals at the county level, through case report sheets, as they are reported according to the Romanian legislation. Methods: We performed a cross sectional study design based on the case law of the data reported to the Mures Public Health Directorate, by all the public hospitals belonging to this county. We tracked hospital-acquired infections reported for 2017–2018, respectively, a number of 1024 cases, which implies a prevalence rate of 0.44%, 1024/228,782 cases discharged from these hospitals during the studied period. Results: The most frequent HAIs were reported by the intensive care units (48.4%), the most common infections being the following: bronchopneumonia (25.3%), enterocolitis with Clostridioides difficile (23.3%), sepsis, surgical wound infections and urinary tract infections. At the basis of HAI were 22 pathogens, but the five most common germs were Clostridioides difficile, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus. Bronchopneumonia have been most frequently reported in intensive care units, the most common being identified the Acinetobacter baumannii agent. Sepsis and central catheter infections also appeared predominantly in intensive care units, more often with Klebsiella pneumoniae. The enterocolitis with Clostridioides difficile, were the apanage of the medical sections. Infections with Staphylococcus aureus have been identified predominantly in the surgical sections at the level of the surgical wounds. Urinary infections had a similar distribution in the intensive care units, the medical and surgical sections, with Klebsiella pneumoniae being the most commonly incriminated agent. Conclusions: We showed a clear correspondence between the medical units and the type of HAI: what recommends the rapid, vigilant and oriented application of the prevention and control strategies of the HAI.

The COVID-19 pandemic represents a major global health crisis, with clinical manifestations ranging from asymptomatic infection to fatal outcomes. While all individuals are susceptible, specific populations, particularly those with pre-existing medical conditions, face a heightened risk of severe disease. This study aimed to assess the prevalence of severe COVID-19 among hospitalized patients with comorbidities in the Central Region of Romania, and to analyze the association between these conditions and mortality. We conducted a retrospective cohort study using data from the Corona Forms platform (2020–2022), encompassing hospitalized cases across three Romanian counties. A total of 1458 patients with confirmed SARS-CoV-2 infection and documented comorbidities were included. Demographic characteristics, comorbid conditions, and hospitalization outcomes were analyzed. The overall mortality rate among comorbid patients was 89.3%. Renal, neurologic, hepatic disease, cardiovascular conditions, obesity, type 2 diabetes mellitus, and cerebrovascular accidents are significant risk factors for death outcomes in the SARS-CoV-2-infected study population. The strength of their association varies, with odds ratios ranging from 25.32 to 1. The findings underscore the critical impact of comorbidities on COVID-19 severity and mortality among the Central Romanian population, emphasizing the necessity of targeted clinical interventions and public health strategies to protect high-risk populations.

Background and Objectives: Romania ranks among the countries with a particularly high rate of mortality that can be prevented through prevention programs, screening, early detection, and prompt care. Cervical cancer (CC) is a major cause of these preventable deaths, affecting individuals from marginalized and rural regions, as well as the Roma population. The purpose of this article was to identify accurate and consistent information about the Roma population on the risk of CC, as well as the importance of understanding the causes of the disease and awareness of the available prevention methods. Materials and Methods: A cross-sectional study was conducted using a self-administered questionnaire applied only to Roma women in Romania. Results: We enrolled 759 patients in this study. These were divided into two groups: Group 1 comprised 289 (38.1%) women who had been tested for HPV infection, while Group 2 included 470 (61.9%) women who had never been tested for HPV infection. Characterization of women in Group 1: mostly aged between 25 and 54 years, with high school education, married, who started sexual activity under the age of 18 years, with only one sexual partner, and had over five pregnancies. Regarding contraceptive methods, 35.7% of women do not know or use any contraceptive method, and 32.2% use hormonal contraceptives. Two thirds of the women tested had heard of HPV, and 19.7% were vaccinated against HPV with at least 2–3 doses. A percentage of 8.7 had a diagnosis of CC, compared to those who were not tested (p-0.0001), whereas 63% of the tested women did not know much about CC, as opposed to 85.7% of the group of untested women. Conclusions: Cervical cancer (CC) continues to be a public health concern in Romania, particularly among vulnerable groups. Promoting campaigns to raise awareness for HPV vaccination and CC screening are necessary to reduce the associated mortality and morbidity.

Background: This study is particularly relevant to the Romanian context, where relatively few empirical investigations have examined post-pandemic health perceptions and levels of trust in public institutions. The purpose of this study is to investigate the long-term impact of the COVID-19 pandemic on health perceptions and trust in the healthcare system by examining key socioeconomic and epidemiological factors. Methods: A cross-sectional online survey was conducted among Romanian adults (N = 423), between March and April 2025. Demographic data, lifestyle habits, mental health, and access to healthcare were assessed. Statistical analyses included both bivariate (chi-square test) and multivariable logistic regression models to identify independent associations. Results: 31.9% of participants reported increased stress and anxiety during the pandemic. Decreased trust in the healthcare system (75.6%) and a perceived reduction in life expectancy (74.3%) were also noted as a consequence of the COVID-19 pandemic. Perceived life expectancy decline was linked to lower education and inconsistent healthcare behavior. Conclusion: In our sample, the perception of decreased life expectancy reflects not only epidemiological realities but also emotional and social responses to crises. Individuals’ trust, behavior, and shared vision of the future have also been challenged during the COVID-19 pandemic.

With acne as one of the most common and frequent conditions of young adult patients, we looked for significant associations, associated conditions with influence on the skin condition with the idea of outlining a different approach of the acne patient. With a multifactorial, multi-disciplinary etiopathogeny, the purpose of this study was to highlight the factors involved in the pathogenesis of this condition and to identify those that should be taken into account when prescribing the treatment.

Background: Healthcare-associated infections (HAIs), particularly those caused by antimicrobial-resistant pathogens, remain an important cause of adverse outcomes among hospitalized patients. The combined contribution of antimicrobial resistance, clinical characteristics, and antimicrobial treatment to mortality requires further evaluation. This study aimed to investigate factors associated with in-hospital mortality among patients with HAIs, with particular emphasis on multidrug resistance (MDR) and post-culture antimicrobial treatment. Methods: We conducted a retrospective observational cohort study that included 192 patients with 242 documented HAI episodes in a hospital in Târgu-Mureș, Romania. Demographic and clinical characteristics, invasive procedures, microbiological findings, antimicrobial resistance phenotypes, antimicrobial exposure, and in-hospital outcome were evaluated. Comparisons between survivors and non-survivors were performed using the Mann–Whitney U test, Pearson’s chi-square test, or Fisher’s exact test, as appropriate. Factors associated with in-hospital mortality were investigated using univariable and multivariable logistic regression. Results: Overall, 161/192 patients (83.9%) died during hospitalization. Non-survivors were significantly older than survivors [median: 71 (IQR: 62–78) vs. 62 (50.5–72) years; p = 0.025]. MDR organisms were more common among non-survivors (51.6% vs. 22.6%; p = 0.003), and MDR phenotype was associated with increased odds of mortality in univariable analysis (OR = 3.65, 95% CI: 1.49–8.95; p = 0.005). After adjustment for age, mechanical ventilation, and recent surgery, MDR remained independently associated with in-hospital mortality (aOR = 3.58, 95% CI: 1.42–8.98; p = 0.007). In the treatment-focused model, aminopenicillin exposure (aOR = 0.21, 95% CI: 0.07–0.64; p = 0.006), second-generation aminoglycosides (aOR = 0.23, 95% CI: 0.06–0.97; p = 0.045), and third-generation cephalosporins (aOR = 0.35, 95% CI: 0.14–0.88; p = 0.025) were associated with lower odds of mortality. No significant association was observed between time to specific antimicrobial therapy and mortality (p = 0.541). Conclusions: MDR was the main antimicrobial-resistance factor independently associated with in-hospital mortality among patients with HAIs. Although several antimicrobial classes were associated with lower odds of death, these observational associations should not be interpreted as causal treatment effects. The findings emphasize the importance of antimicrobial resistance surveillance, rapid microbiological diagnosis, antimicrobial stewardship, and timely access to active antimicrobial therapy.