Eugenio Barone, is Associate Professor of Biochemistry at Sapienza University of Rome (IT). He graduated in Pharmaceutical Chemistry and Technology in 2006 and got a PhD in Neuroscience in 2011. The overarching goal of his laboratory is to clarify the link beteween defects of neurotrophic signaling (insulin and GLP1) and increased cell oxidative damage during ageing and neurodegeneration. He discovered the oxidative-induced impairment of biliverdin reductase-A (BVR-A) protein as an early event accelerating brain insulin resistance development. Indeed, BVR-A impairment is antecedent to canonical pathways driving insulin resistance [Free Rad Biol Med (2016)], thus becoming of interest either as biomarker or as pharmacological target. Furthermore, during the last years he focused on Down syndrome (DS) and his lab demonstrated for the fisrt time that brain insulin resistance develops very early in DS, independenlty of peripheral alterations [Neurobiol Dis (2020); Free Rad Biol Med (2021); Alzheimer’s and Dementia (2021)]. Eugenio authored 92 publications, most of wich dealing with the role of oxidative stress in neurodegenerative disorders, i.e., Alzheimer’s disease and DS. He He was recipient of prestigious international and national grants from the Alzheimer’s Association (2020-24), Jerome Lejeune Foundation (2019-21 and 2022-24), European Commission (2014-16) and Italian Ministry of Research (2015-18), among the others. Eugenio was one of the firsts two repients of the SFRBM