Since 2015 as a bioengineer and a PhD student, I have been working with biomimetic materials and development of artificial organs (artificial pancreas/ artificial ovary). This experience helped me conclude that the development of an artificial ovary requires more than the utilization of biomaterials and application of tissue engineering strategies. Indeed, an essential requirement for reproducing the complexity of a functional ovary is a comprehensive understanding of the composition, architecture, biomechanical properties and plasticity of the human ovary extracellular matrix, which have not been sufficiently elucidated so far. To achieve this goal, I did not only develop my PhD project in close collaboration with multidisciplinary teams from Belgium and abroad, but I also proactively contributed in its design, through developing tailored techniques and methods for reliable characterization of human ovarian tissue. I have successfully provided in a short amount of time the first readout of proteomic, architectural and biophysical properties of healthy human ovarian tissue from prepuberty til menopause for future tissue engineering, clinical applications and prognosis. My pioneering findings represent the first conclusive link between ovarian matrisome and fertility and pave the way for a better understanding of the mechanisms by which ovarian cells respond to ECM cues.