Dr. Bingwen Eugene Fan
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Academic Career Length
13Years (2014-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications4 March 2020 in American Journal of Hematology
Journal Article
Bingwen Eugene FanVCVanessa Cui Lian Chong
Vanessa Cui Lian Chong
SCStephrene Seok Wei Chan
Stephrene Seok Wei Chan
GLGek Hsiang Lim
Gek Hsiang Lim
KLKian Guan Eric Lim
Kian Guan Eric Lim
KOKiat Hoe Ong
Kiat Hoe Ong
+3
Click on the article title to read more.
16 October 2020 in Nature Communications
Journal Article
GCGuillaume Carissimo
Guillaume CarissimoWXWeili Xu
Weili Xu
IKImmanuel Kwok
Immanuel Kwok
MAMohammad Yazid Abdad
Mohammad Yazid AbdadYCYi-Hao Chan
Yi-Hao ChanLNLisa F.P. Ng
Lisa F.P. Ng +18
SARS-CoV-2 is the novel coronavirus responsible for the current COVID-19 pandemic. Severe complications are observed only in a small proportion of infected patients but the cellular mechanisms underlying this progression are still unknown. Comprehensive flow cytometry of whole blood samples from 54 COVID-19 patients reveals a dramatic increase in the number of immature neutrophils. This increase strongly correlates with disease severity and is associated with elevated IL-6 and IP-10 levels, two key players in the cytokine storm. The most pronounced decrease in cell counts is observed for CD8 T-cells and VD2 γδ T-cells, which both exhibit increased differentiation and activation. ROC analysis reveals that the count ratio of immature neutrophils to VD2 (or CD8) T-cells predicts pneumonia onset (0.9071) as well as hypoxia onset (0.8908) with high sensitivity and specificity. It would thus be a useful prognostic marker for preventive patient management and improved healthcare resource management.
28 April 2022 in American Journal of Hematology
Journal Article
Bingwen Eugene FanSWShiun Woei Wong
Shiun Woei Wong
CSChristina Lai Lin Sum
Christina Lai Lin Sum
GLGek Hsiang Lim
Gek Hsiang Lim
BLBernard Leung
Bernard LeungTIThe COVID‐19 Clotting and Bleeding Investigators
The COVID‐19 Clotting and Bleeding Investigators
+10
29 May 2020 in American Journal of Hematology
Journal Article
Bingwen Eugene FanClick on the article title to read more.
7 November 2020 in Journal of Thrombosis and Thrombolysis
Journal Article
Bingwen Eugene FanTUThirugnanam Umapathi
Thirugnanam Umapathi
KCKaren Chua
Karen Chua
YCYew Woon Chia
Yew Woon Chia
SWShiun Woei Wong
Shiun Woei Wong
RDRinkoo Dalan
Rinkoo Dalan
+4
15 March 2020 in American Journal of Hematology
Journal Article
Bingwen Eugene FanKLKian Guan Eric Lim
Kian Guan Eric Lim
VCVanessa Cui Lian Chong
Vanessa Cui Lian Chong
SCStephrene Seok Wei Chan
Stephrene Seok Wei Chan
KOKiat Hoe Ong
Kiat Hoe Ong
PKPonnudurai Kuperan
Ponnudurai Kuperan
About Me
I am a consultant haematologist at Tan Tock Seng Hospital, Singapore and honorary haematologist at Northern Health (Victoria) Australia, with research interests in AI-driven diagnostics, thrombosis and haemostasis, medical innovation, and sustainability in healthcare. I serve as an associate editor for Seminars in Thrombosis & Hemostasis (STH), Research and Practice in Thrombosis and Haemostasis (RPTH), the Annals of Hematology and the editorial board of the American Journal of Hematology. My work focuses on AI-enabled peripheral blood-film analysis, laboratory and clinical applications for thrombosis and haemostasis, and point-of-care and diagnostic medical devices that are supported by several filed patents. As a 2024 Singapore Biodesign Innovation Fellow and Centre for Healthcare Innovation (CHI) Faculty, I aim to translate evidence-based insights into scalable, patient-centred solutions. I am grateful to receive research funding from both the National Medical Research Council and the National Health Innovation Centre.