Felipe Henrique de Souza Silva

Dr. Felipe Henrique de Souza Silva

orcid

Research Focus & Metrics

Academic Career Length

9Years (2018-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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16 August 2018 in Cell Biology International
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Journal Article
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CACamila P. Almeida
Camila P. Almeida
MFMárcia C. F. Ferreira
Márcia C. F. Ferreira
CSCamila O. Silveira
Camila O. Silveira
JCJacira R. Campos
Jacira R. Campos
IBIsabella T. Borges
Isabella T. Borges
HPHelen Lima Del Puerto
Helen Lima Del Puerto

29 September 2022 in Medical Oncology
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Journal Article
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Felipe Henrique de Souza SilvaFelipe Henrique de Souza Silva
Felipe Henrique de Souza Silva
AUAdam Underwood
Adam Underwood
CACamila Pereira Almeida
Camila Pereira Almeida
TRThais Salviana Ribeiro
Thais Salviana Ribeiro
ESElaine M. Souza-Fagundes
Elaine M. Souza-Fagundes
HPHelen Lima Del Puerto
Helen Lima Del Puerto

22 October 2022 in Scientific Reports
Verified
Journal Article
Open access
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EVEmerson Soares Veloso
Emerson Soares Veloso
BCBárbara Andrade de Carvalho
Bárbara Andrade de Carvalho
Felipe Henrique de Souza SilvaFelipe Henrique de Souza Silva
Felipe Henrique de Souza Silva
TRThaís Salviana Ribeiro
Thaís Salviana Ribeiro
BLBruna Mendes Lima
Bruna Mendes Lima
EFEnio Ferreira
Enio Ferreira
Melanoma is an aggressive cancer with fast metastatic spread and reduced survival time. One common event during the neoplastic progression is the epithelial–mesenchymal transition (EMT), which enhances invasiveness, cell migration, and metastasis. In this study, we investigated the effects of metformin at EMT in melanoma cell lines B16-F10 and A-375, in vitro, and the impact of EMT downregulation on melanoma progression in vivo. The metformin cells treatment reduces the migration potential in vitro and reduced the development of pulmonary metastases and the expressions of N-cadherin, vimentin, ZEB1, and ZEB2 at the metastases site, in vivo. These results indicate that metformin can promote EMT downregulation impairing the metastatic potential of melanoma cells.

13 June 2024 in Genes
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Journal Article
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HPHelen Lima Del Puerto
Helen Lima Del Puerto
AMAna Paula G. S. Miranda
Ana Paula G. S. Miranda
DQDinah Qutob
Dinah Qutob
EFEnio Ferreira
Enio Ferreira
Felipe Henrique de Souza SilvaFelipe Henrique de Souza Silva
Felipe Henrique de Souza Silva
AUAdam Underwood
Adam Underwood
Members of the SOX (SRY-related HMG box) family of transcription factors are crucial for embryonic development and cell fate determination. This review investigates the role of SOX3 in cancer, as aberrations in SOX3 expression have been implicated in several cancers, including osteosarcoma, breast, esophageal, endometrial, ovarian, gastric, hepatocellular carcinomas, glioblastoma, and leukemia. These dysregulations modulate key cancer outcomes such as apoptosis, epithelial-mesenchymal transition (EMT), invasion, migration, cell cycle, and proliferation, contributing to cancer development. SOX3 exhibits varied expression patterns correlated with clinicopathological parameters in diverse tumor types. This review aims to elucidate the nuanced role of SOX3 in tumorigenesis, correlating its expression with clinical and pathological characteristics in cancer patients and cellular modelsBy providing a comprehensive exploration of SOX3 involvement in cancer, this review underscores the multifaceted role of SOX3 across distinct tumor types. The complexity uncovered in SOX3 function emphasizes the need for further research to unravel its full potential in cancer therapeutics.

1 February 2021 in Acta Histochemica
Verified
Journal Article
Closed access
CACamila P. Almeida
Camila P. Almeida
CSCamila O. Silveira
Camila O. Silveira
EFEnio F. Ferreira
Enio F. Ferreira
MFMarcia C. Ferreira
Marcia C. Ferreira
GOGabriella G. Oliveira
Gabriella G. Oliveira
HPHelen L. Del Puerto
Helen L. Del Puerto

5 May 2022 in Reproductive Sciences
Verified
Journal Article
Closed access
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CSCamila O. Silveira
Camila O. Silveira
RORafaela M. Oliveira
Rafaela M. Oliveira
LMLeonardo M. Moraes
Leonardo M. Moraes
GOGabriella G. Oliveira
Gabriella G. Oliveira
LALuciana P. T Aguiar
Luciana P. T Aguiar
MFMarcia C. F. Ferreira
Marcia C. F. Ferreira