Francis Lopes Pacagnelli is a researcher whose work focuses primarily on cardiovascular physiology, cardiac remodeling, and skeletal muscle biology. She investigates the impact of environmental toxins, endocrine disruptors, and metabolic disorders on cardiac tissue integrity and muscle physiology. Her research interests the effects of physical training on molecular, structural, and functional adaptations of the heart and skeletal muscle in experimental models of hypertension, heart failure, and pulmonary hypertension. More recently, his work has expanded to include the use of artificial intelligence to study microRNA-mediated regulation of muscle atrophy. He has published extensively in the fields of cardiac remodeling, exercise physiology, toxicology, and rehabilitation, and supervises research projects at the undergraduate, master’s, and doctoral levels. Her scientific trajectory integrates molecular biology, morphofunctional analysis, and exercise-based interventions to better understand mechanisms of cardiovascular and muscular adaptation in health and disease.