Dr. GAURAV PRAKASH
Department of Chemistry and Biochemistry, The University of Texas at Dallas, Richardson, Texas, USA
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Academic Career Length
7Years (2020-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications23 March 2022 in Chemical Society Reviews
Journal Article
GAURAV PRAKASHNPNilanjan Paul
Nilanjan Paul
GOGwyndaf A. Oliver
Gwyndaf A. Oliver
DWDaniel B. Werz
Daniel B. WerzDMDebabrata Maiti
Debabrata MaitiThis review summarises deuteration methods of various organic motifs containing C(sp 2 )−H and C(sp 3 )−H bonds utilizing C−H bond functionalisation as a key step along with a variety of catalysts, and exemplifies their biological relevance.
29 January 2021 in Chemical Science
Journal Article
Transition metal-catalysed functionalizations of inert C–H bonds to construct C–C bonds represent an ideal route in the synthesis of valuable organic molecules. Fine tuning of directing groups, catalysts and ligands has played a crucial role in selective C–H bond (sp2 or sp3) activation. Recent developments in these areas have assured a high level of regioselectivity in C–H olefination reactions. In this review, we have summarized the recent progress in the oxidative olefination of sp2 and sp3 C–H bonds with special emphasis on distal, atroposelective, non-directed sp2 and directed sp3 C–H olefination. The scope, limitation, and mechanism of various transition metal-catalysed olefination reactions have been described briefly.
28 February 2022 in Nature Communications
Journal Article
JGJagrit Grover
Jagrit Grover
GAURAV PRAKASHNGNupur Goswami
Nupur Goswami
DMDebabrata Maiti
Debabrata MaitiBiaryl scaffolds are found in natural products and drug molecules and exhibit a wide range of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction came out as an effective tool for the construction of biaryl motifs. However, traditional transition metal-catalyzed C–H arylation reactions have limitations like harsh reaction conditions, narrow substrate scope, use of additives etc. and therefore encouraged synthetic chemists to look for alternate greener approaches. This review aims to draw a general overview on C–H bond arylation reactions for the formation of C–C bonds with the aid of different methodologies, majorly highlighting on greener and sustainable approaches.
20 January 2022 in Journal of the American Chemical Society
Journal Article
ASArgha Saha
Argha Saha
SGSrimanta Guin
Srimanta Guin
WAWajid Ali
Wajid Ali
TBTrisha Bhattacharya
Trisha Bhattacharya
SSSheuli Sasmal
Sheuli Sasmal
DMDebabrata Maiti
Debabrata Maiti +6
19 August 2020 in Chemical Science
Journal Article
JDJayabrata Das
Jayabrata DasPDPravas Dolui
Pravas Dolui
WAWajid Ali
Wajid Ali
JBJyoti Prasad Biswas
Jyoti Prasad Biswas
HCHediyala B. Chandrashekar
Hediyala B. Chandrashekar
DMDebabrata Maiti
Debabrata Maiti +1
Lactones comprise a class of valuable compounds having biological as well as industrial importance. Development of a methodology to synthesize such molecules directly from readily available materials such as aliphatic carboxylic acid is highly desirable. Herein, we have reported synthesis of δ-lactones and ε-lactones via selective γ-C(sp3)–H activation. The γ-C–H bond containing aliphatic carboxylic acids provide six or seven membered lactones depending on the olefin partner in the presence of a palladium catalyst. A mechanistic investigation suggests that C–H activation is the rate-determining step. Further transformations of the lactones have been carried out to showcase the applicability of the present strategy.
30 March 2023 in Green Chemistry
Journal Article
JGJagrit Grover
Jagrit Grover
GAURAV PRAKASHCTChitrala Teja
Chitrala Teja
GLGoutam Kumar Lahiri
Goutam Kumar LahiriDMDebabrata Maiti
Debabrata MaitiA mild metal-free approach for C(sp 3 )–H thioarylation of organic building blocks.
About Me
Dr. Gaurav Prakash is a Postdoctoral Research Scholar at the University of Texas at Dallas, working under the supervision of Prof. Vladimir Gevorgyan. He earned his PhD in Chemistry from the Indian Institute of Technology Bombay in June 2024, where his thesis focused on regioselective C-H functionalization utilizing thermal and photoinduced approaches in batch and continuous flow systems under the guidance of Prof. Debabrata Maiti. Dr. Prakash also holds a Master of Science in Chemistry with Distinction from Aligarh Muslim University and a Bachelor of Science in Chemistry from the University of Delhi.
His technical expertise encompasses C-H functionalization, photochemistry, flow chemistry, and high-throughput experimentation. Throughout his career, he has successfully developed new methodologies for regioselective C-H functionalization, asymmetric catalysis and scale-up reactions.