Biomimicry is a relatively new discipline of applied science that seeks inspiration from natural systems for innovative solutions to human problems. Taking nature as ‘model, mentor and measure’ receives wide acceptance in the field of architecture but predominantly in conceptualising novel forms. The biomimicry concept is comprehensively analysed for its ability to provide more sustainable and possibly even regenerative built environments. As part of this study, first, various frameworks for approaching ‘biomimicry’ in general are discussed and then relevant examples pertaining to architecture are evaluated. Case studies are critiqued with respect to varied levels of sustainability achieved and its causative factors. In the second part, an approach model for ‘biomimetic architecture’ in the context of Mumbai is presented and applicable strategies based on climatic adaptation are suggested using local biodiversity as a library of organisms. The generic example of ‘human skin’ addressing the same adaptation is analysed and complemented by a state-of-the-art case study on similar lines. The results achieved clearly reveal that biomimicry is a successful approach to design and operate the sustainable built environments for the buildings of the future.