By monitoring the alternating interference voltage at the intersections and parallels of gas pipelines with high-speed railways, the alternating voltage between the high-speed railway track supports and the ground, the alternating ground voltage gradient along parallel and perpendicular high-speed railway tracks, and the timing of train passages, the interference patterns caused by high-speed railways on pipelines are analyzed. A numerical model was developed to elucidate interference mechanisms. The conclusions indicate that the interference caused by the parallel and intersecting presence of high-speed railways and pipelines is far greater than that caused solely by the intersection of railways and pipelines. The peak alternating voltage interference on pipelines occurs at the insulation joints of the pipelines, the positions of the pipelines corresponding to the high-speed railway track circuits (AT), and the positions of the pipelines corresponding to the passage of trains. The alternating interference caused by high-speed railway lines on pipelines involves both resistive coupling interference and electromagnetic induction coupling interference, with the latter dominating.