Purpose: Myxoid liposarcoma (MLPS) is a malignant tumor that occurs predominantly in the deep soft tissues of the extremities. Preoperative radiotherapy (RT) is used to reduce tumor volume to achieve adequate surgical margins. This systematic review aims to evaluate the impact of preoperative RT on surgical margins, local recurrence (LR) rates, metastasis development, and overall survival in patients with MLPS and associated prognostic factors. Methods: A systematic literature search was conducted by two reviewers following PRISMA guidelines on PubMed, Scopus, and the Cochrane Library on 30 November 2024. We included prospective and retrospective cohort studies published in English that evaluate surgical margin status, LR and metastasis rates, and survival outcomes in patients undergoing surgical excision of MLPS following neoadjuvant radiotherapy. Two authors extracted tumor characteristics, percentage of round cells (RCs), change in tumor volume post-RT, surgical margins, postoperative complications, LR and metastasis rates, survival rates, and related prognostic factors. Results: The twelve studies included in this review involved 1483 patients with a mean age of 44.8 years. Tumors were mostly located in the lower limbs, deeply localized, and larger than 5 cm in most cases. The average LR and metastasis rates were 5.2% and 17%, respectively. The mean 5-year and 10-year overall survival rates were 87% and 74%, respectively. Poor prognosis was associated with >5% RC components, tumors larger than 15 cm, deep localization, and inadequate surgical margins. Conclusion: The management of MLPS requires a multidisciplinary approach. Preoperative radiotherapy offers several advantages in reducing tumor volume and facilitating the achievement of adequate surgical margins, finally improving local control and long-term outcomes.

The glomus tumor (GT) is a rare benign neoplasm, generally located in the subungual region of the distal phalanx of the fingers as a single nodule. While approximately 90% of digital GTs are correctly diagnosed (pain, cold sensitivity, and point tenderness), extradigital forms often present with silent or atypical features, complicating diagnosis. The treatment of choice is surgical excision, associated with low recurrence rates. In October 2022, a 64‐year‐old man presented with a painful, palpable mass in the distal third of the right femur. Magnetic resonance and computed tomography revealed a solid lesion involving the distal third of the femur. A needle biopsy confirmed the diagnosis of GT with hemangiopericytoma‐like features. In January 2023, surgical excision was performed, and histology confirmed the diagnosis. The patient had a significant oncologic history: In 1994, he underwent wide resection and adjuvant chemotherapy for a high‐grade undifferentiated sarcoma of the right thigh. In November 2012, he reported a painful mass in the right ankle, and excisional biopsy with immunohistochemistry led to a diagnosis of multifocal GT. At his last follow‐up in November 2025, he was in good general health under oncologic surveillance. We conducted a search on PubMed and Scopus using the keywords “extra digital glomus tumor” and included articles reporting extra digital GTs of the lower limb. The literature review identified 143 patients with extradigital GT with lower limb involvement. This case represents a rare presentation because of its unusual lower limb location, with lesions in the ankle in 2012 and the femur in 2022. We report a rare case of a late metachronous extradigital GT of the lower limb in an unusual anatomical site.

Background: Carpal tunnel release (CTR) surgery may have an impact on the speed and accuracy of handwriting and digital typing using a computer or mobile devices. Methods: In this prospective cohort study, patients undergoing CTR surgery of the dominant hand, between 18 and 70 years of age, with frequent use of a QWERTY keyboard and smartphone were included. A baseline Visual Analog Scale (VAS) for subjective alteration of writing and Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) were collected at a maximum 3-month follow-up. Digital typing speed (word per minute, wpm) and accuracy (number of mistakes) were tested. Handwriting was assessed by means of direct supervision of one investigator. Results: Of the 30 enrolled patients, 23 (76.7%) completed the 3-month follow-up and were included in the final analysis (mean age 55 ± 12.3 years). Pre- and post-surgery improvements in keyboard typing speed (14.8 ± 6.8 wpm to 17.6 ± 5 wpm) and mobile texting speed (16.7 ± 5.9 wpm to 21.7 ± 6.5 wpm) were significantly improved over time. Accuracy improved significantly only in keyboard typing, where the mean number of errors was reduced (13.1 ± 8.2 to 9.9 ± 5.6). QuickDASH scores decreased significantly (39.1 ± 9.1 to 17 ± 6). Conclusions: CTR surgery was associated with improved typing speed and reduced the number of errors (19% and −24%, respectively) as well as texting speed (30%). This improvement may be relevant in daily and occupational activities, as reported in the previous literature.