In the Bioscience department at the University of Texas at El Paso, Alice H. Grant has been studying tyrosine kinases and cell signaling in lymphocytes as they relate to Leukemia. This cancer has an unequal burden of incidence and mortality amongst children, especially in minority and underserved populations. Acute Lymphoblastic Leukemia is second in cancers causing the most deaths in children. The major focus of her research has been the identification of novel mutants and their structural and functional consequence on Janus Kinase (JAK1), a tyrosine kinase frequently dysregulated in ALL.