Abnormalities in the plasma amino acid and/or urinary organic acid profile have been reported in autism spectrum disorder (ASD). An imbalance between excitatory and inhibitory neuronal activity has been proposed as a mechanism to explain dysfunctional brain networks in ASD, as also suggested by the increased risk of epilepsy in this disorder. This study explored the possible association between presence of EEG paroxysmal abnormalities and the metabolic profile of plasma amino acids and urinary organic acids in children with ASD. In a sample of 55 children with ASD (81.8% male, mean age 53.67 months), EEGs were recorded, and 24 plasma amino acids and 56 urinary organic acids analyzed. EEG epileptiform discharges were found in 36 (65%) children. A LASSO regression, adjusted by age and sex, was applied to evaluate the association of plasma amino acids and urinary organic acids profiles with the presence of EEG epileptiform discharges. Plasma levels of threonine (THR) (coefficient = −0.02, p = 0.04) and urinary concentration of 3-Hydroxy-3-Methylglutaric acid (HMGA) (coefficient = 0.04, p = 0.02) were found to be associated with the presence of epileptiform discharges. These results suggest that altered redox mechanisms might be linked to epileptiform brain activity in ASD.

Given the importance of youth mental health for public policy, it is crucial to involve young people directly in participatory research to investigate their views and translate their demands into concrete actions. The aim of the study was to define the concept of mental wellbeing as perceived by a group of adolescent and young adult patients in two large hospitals in northwestern Italy and to find out, together with them, what institutions can do to promote youth wellbeing. Thirty-nine participants (13–25 years old, 90% female), divided into four groups, took part in a Photovoice workshop. Individual interviews were conducted with 21 participants and the transcripts were thematically analyzed. The photos were categorized into five themes: nature, traveling, passions and leisure, relationships, and animals. The definition of mental wellbeing can be traced back to eight themes: sharing experiences and emotions with others, calm and tranquility, personal fulfilment, sense of belonging, pleasant physical sensations, freedom and discovery, involvement and commitment, and happiness. The key recommendations for promoting mental wellbeing were providing information about mental health, tackling the stigma of mental illness, and providing psychological support in school and health services. The implications of these findings for policy makers involved in planning health services for young people are discussed.