I am Professor of Molecular Genetics and Biotechnology at the University of Tours, France. My research is driven by a central question: how do genetic and epigenetic alterations shape the extreme aggressiveness and adaptability of glioblastoma (GB)? By exploring these mechanisms, my team seeks not only to understand tumor evolution, but also to turn its vulnerabilities into therapeutic opportunities. A major focus of our work is the protein S-SETMAR. We have developed an original therapeutic strategy based on its ability to induce chromosomal chaos in GB cells, thereby increasing their sensitivity to conventional treatments. Rather than protecting genome stability, we aim to transiently destabilize tumor cells to push them beyond their tolerance threshold. This innovative approach has led to a patented strategy that we are further advancing toward translational development. Beyond the laboratory, I am deeply committed to science communication. I engage regularly with the general public and write books—including scientific essays and science-based crime novels—to share the intellectual adventure of research and foster dialogue between science and society.