Dr. Wei’s research focuses on investigating swine gut microbes and immunity. Our study mainly applied metagenomics, metabolomics, transcriptomics and other techniques to study the effects of early weaning on the structure and function of intestinal microecology, so as to reveal the target microbial community and the internal immune mechanism in the intestinal microecology in response to dietary fiber. We investigates the dynamic changes in dietary fiber metabolism by gut microbiota in Chinese native pigs and commercial pigs. Utilizing an in vitro fermentation model of intestinal microbiota to explore the succession patterns of microbial communities and their functional evolution. We also focuses on the issue of porcine pulmonary inflammatory lesions affecting swine health. Utilizing multi-omics technologies and adopting a gut-lung axis perspective to investigate the process and underlying mechanisms by which gut microbiota participate in regulating pulmonary inflammatory responses. The research elucidates the impact of targeted gut microbiota on pulmonary health and ultimately aims to enhance swine production efficiency through nutritional regulation, specifically by examining the regulatory mechanisms of dietary fiber on gut microbiota.