Jaberi-Douraki's research broadly involves computational and mathematical biology, elements of statistical and machine learning, and predictive model development using data science and big data. He leads the 1DATA consortium, a collaborative partnership between Kansas State University and the University of Missouri–Kansas City. The 1DATA platform cleans and standardizes preclinical human and animal health data and adds it to a data clearinghouse. Jaberi-Douraki and his team have developed an intelligent medicine recommender system, called 1DrugAssist, using several national and international databases to evaluate the prevalence of adverse drug events (ADEs), including different cancer types reported to the FDA.