Ms. Jahanvi Patel
Department of Pharmacy and chemistry, Kingston University, London, City of London, UK
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Academic Career Length
1Year (2026-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Insulin delivery via the buccal route has shown long-standing promise for diabetes therapy, but clinical translation remains limited. Most systems address only part of the delivery problem, whereas a viable product must simultaneously provide adequate insulin residence time, effective mucus and epithelial permeation, stability, dose consistency, safety, and manufacturability. This review examines the biological and formulation barriers limiting buccal insulin delivery and compares major platform types, including mucoadhesive films and patches, nanocarrier-based systems, deformable vesicles, chemistry-led permeation approaches, and device-enabled strategies. Stability, alongside limited permeability, is considered a key barrier, while aggregation and excipient-related instability remain insufficiently addressed. This review also discusses why promising preclinical findings often fail to translate, exhibiting low bioavailability, variability, safety concerns, and scale-up challenges recurring across platforms. Overall, further progress in buccal insulin delivery will depend on formulation strategies that better integrate permeation enhancement, stability preservation, and translational feasibility.
Preprint
Insulin delivery via the buccal route has shown long-standing promise for diabetes therapy, but clinical translation remains limited. Most systems address only part of the delivery problem, whereas a viable product must simultaneously provide adequate insulin residence time, effective mucus and epithelial permeation, stability, dose consistency, safety, and manufacturability. This review examines the biological and formulation barriers that limit buccal insulin delivery and compares the major platform types, including mucoadhesive films and patches, nanocarrier-based systems, deformable vesicles, chemistry-led permeation approaches, and device-enabled strategies. Stability, alongside limited permeability, is considered a key barrier, while aggregation and excipient-related instability remain insufficiently addressed. The review also discusses why promising preclinical findings often fail to translate, exhibiting low bioavailability, variability, safety concerns, and scale-up challenges recurring across platforms. Overall, further progress in buccal insulin delivery will depend on formulation strategies that better integrate permeation enhancement, stability preservation, and translational feasibility.
About Me
I am a pharmaceutical professional with an MSc in Pharmaceutical Science from the University of Greenwich. I am currently pursuing a PhD focused on the development and optimization of buccal formulations for the delivery of proteins and other macromolecular therapeutics at University of Kingston.
My professional journey spans pharmaceutical practice, manufacturing, clinical work, academic research, and higher education. I have gained divers experience as a pharmacist, pharmaceutical manufacturing professional, Clinical research associate, and Teaching Assistant. These roles have provided me with a broad understanding of the pharmaceutical pathway—from early-stage research and formulation development to manufacturing, clinical application, patient care, and the education of future professionals.
I have a strong interest in pharmaceutical research and development (R&D), particularly in advanced drug-delivery systems, formulation development, process optimization, and translating scientific discoveries into practical therapies. Through my doctoral research and multidisciplinary professional experience, I aim to build a career in pharmaceutical R&D and contribute to innovative, effective, and patient-centred therapeutic solutions.