Rabies, a zoonotic viral disease, poses a significant threat due to its adaptability to diverse environments. Herbivore rabies, predominantly affecting cattle, horses, and goats in Brazil, remains a concern, results in substantial losses in the livestock industry, and poses risks to public health. Rabies virus transmission, primarily through hematophagous bats in Latin America, underscores the need for effective strategies, and vaccination plays a crucial role in controlling herbivorous rabies, with systematic vaccination beingly the primary method. Efforts to control rabies in herbivores include vaccination campaigns, public awareness programs, and the enhancement of surveillance systems. Despite these initiatives, rabies persists and imposes an economic burden and a significant health risk. Economic impacts include losses in the livestock industry, trade restrictions on livestock products, and financial burdens on governments and farmers owing to control measures. Despite the considerable costs of campaigns, surveillance, and control, investing in rabies vaccination and control not only safeguards livestock, but also preserves public health, reduces human cases, and strengthens the sustainability of the livestock industry. Mitigating the impact of herbivorous rabies in Brazil requires integrated approaches and continuous investments in vaccination, surveillance, and control measures to protect public health and ensure the sustainability of the livestock industry, thus contributing to food and economic security.

In countries where poliomyelitis has been eradicated, Guillain–Barré syndrome (GBS) is the leading cause of acute flaccid paralysis. The range of infections that precede GBS in Brazil is unknown. Campylobacter jejuni infection is the most frequent trigger of GBS worldwide. Given the lack of systematic surveillance of diarrheal diseases, particularly in adults, the incidence of enteritis caused by C. jejuni in developing countries is unknown. From 2014 to 2016, pretreatment serum samples from 63 GBS patients were tested by immunoglobulin M (IgM) enzyme-linked immunosorbent assay for C. jejuni. Campylobacter jejuni IgM antibodies were detected in 17% (11/63) of the samples. There was no association between serological positivity (IgM) for C. jejuni and the occurrence of diarrhea among the investigated cases (P = 0.36). Hygiene measures, basic sanitation, and precautions during handling and preparation of food of animal origin may help prevent acute flaccid paralysis.

Heatwaves (HWs) are becoming more frequent and severe, posing a significant threat to human health. Studies have shown that extreme heat, whether as incremental temperature increases or prolonged HWs, is associated with an increased risk of heat-related illnesses. However, there is still limited understanding of how these impacts unfold in Brazil, given its unique social, environmental, and health-system contexts. I this perspective article, we explore the effects of HWs on human physiology, examine the social and biological factors that contribute to heat stress, and identify vulnerable populations at disproportionate risk. We also discuss the potential consequences of extreme heat in other aspects of society, such as agriculture and energy, and assess the challenges of strengthening resilience in Brazil’s health sector. Our key contribution are to make visible the hidden burden of heat-related mortality, to examine how fragmented governance constrains the adaptive capacity of Brazil’s health sector, and to reflect on pathways to strengthen resilience to heatwaves.

Studies have shown that climate may affect the distribution of coronavirus disease (COVID-19) and its incidence and fatality rates. Here, we applied an ensemble niche modeling approach to project the climatic suitability of COVID-19 cases in Brazil. We estimated the cumulative incidence, mortality rate, and fatality rate of COVID-19 between 2020 and 2021. Seven statistical algorithms (MAXENT, MARS, RF, FDA, CTA, GAM, and GLM) were selected to model the climate suitability for COVID-19 cases from diverse climate data, including temperature, precipitation, and humidity. The annual temperature range and precipitation seasonality showed a relatively high contribution to the models, partially explaining the distribution of COVID-19 cases in Brazil based on the climatic suitability of the territory. We observed a high probability of climatic suitability for high incidence in the North and South regions and a high probability of mortality and fatality rates in the Midwest and Southeast regions. Despite the social, viral, and human aspects regulating COVID-19 cases and death distribution, we suggest that climate may play an important role as a co-factor in the spread of cases. In Brazil, there are regions with a high probability that climatic suitability will contribute to the high incidence and fatality rates of COVID-19 in 2020 and 2021.

Objective: To investigate the seroprevalence of Chagas disease (CD) among the rural population of communities within the municipality of Simplício Mendes, located in the state of Piauí, Brazilian semiarid region. Methods: This is a cross-sectional study and serological survey conducted from 2022 to 2023 in 10 rural communities. Capillary blood samples were collected from consenting residents and screened for anti-Trypanosoma cruzi antibodies using the TR Chagas Bio-Manguinhos kit. Positive samples underwent confirmatory testing using ELISA and Indirect Immunofluorescence Assay techniques. Data on sociodemographic characteristics and potential risk factors for CD transmission were collected through a structured questionnaire. Results: The overall serologically confirmed positivity rate in the rural communities of Simplício Mendes municipality was 4.1% (8/195). Older age (> 40 years) and lower levels of formal education were associated with higher seropositivity rates. Triatomine infestation was reported in 71.3% of households, with higher prevalence during the dry season (69.2%). Conclusion: The study highlights the persistent threat of CD in rural communities of Simplício Mendes, Piauí, emphasizing the need for sustained surveillance and control efforts. Socioeconomic and environmental factors contribute to ongoing transmission cycles, underscoring the importance of community engagement and health education initiatives.