Prostate cancer is currently one of the most commonly-diagnosed types of cancer among males. Although its death rate has dropped in the last decades, it is still a major concern and one of the leading causes of cancer death. Prostate biopsy is a test that confirms or excludes the presence of cancer in the tissue. Samples extracted from biopsies are processed and digitized, obtaining gigapixel-resolution images called whole-slide images, which are analyzed by pathologists. Automated intelligent systems could be useful for helping pathologists in this analysis, reducing fatigue and making the routine process faster. In this work, a novel Deep Learning based computer-aided diagnosis system is presented. This system is able to analyze whole-slide histology images that are first patch-sampled and preprocessed using different filters, including a novel patch-scoring algorithm that removes worthless areas from the tissue. Then, patches are used as input to a custom Convolutional Neural Network, which gives a report showing malignant regions on a heatmap. The impact of applying a stain-normalization process to the patches is also analyzed in order to reduce color variability between different scanners. After training the network with a 3-fold cross-validation method, 99.98% accuracy, 99.98% F1 score and 0.999 AUC are achieved on a separate test set. The computation time needed to obtain the heatmap of a whole-slide image is, on average, around 15 s. Our custom network outperforms other state-of-the-art works in terms of computational complexity for a binary classification task between normal and malignant prostate whole-slide images at patch level.

The COVID-19 pandemic caused by the new coronavirus SARS-CoV-2 has changed the world as we know it. An early diagnosis is crucial in order to prevent new outbreaks and control its rapid spread. Medical imaging techniques, such as X-ray or chest computed tomography, are commonly used for this purpose due to their reliability for COVID-19 diagnosis. Computer-aided diagnosis systems could play an essential role in aiding radiologists in the screening process. In this work, a novel Deep Learning-based system, called COVID-XNet, is presented for COVID-19 diagnosis in chest X-ray images. The proposed system performs a set of preprocessing algorithms to the input images for variability reduction and contrast enhancement, which are then fed to a custom Convolutional Neural Network in order to extract relevant features and perform the classification between COVID-19 and normal cases. The system is trained and validated using a 5-fold cross-validation scheme, achieving an average accuracy of 94.43% and an AUC of 0.988. The output of the system can be visualized using Class Activation Maps, highlighting the main findings for COVID-19 in X-ray images. These promising results indicate that COVID-XNet could be used as a tool to aid radiologists and contribute to the fight against COVID-19.

Among all the cancers known today, prostate cancer is one of the most commonly diagnosed in men. With modern advances in medicine, its mortality has been considerably reduced. However, it is still a leading type of cancer in terms of deaths. The diagnosis of prostate cancer is mainly conducted by biopsy test. From this test, Whole Slide Images are obtained, from which pathologists diagnose the cancer according to the Gleason scale. Within this scale from 1 to 5, grade 3 and above is considered malignant tissue. Several studies have shown an inter-observer discrepancy between pathologists in assigning the value of the Gleason scale. Due to the recent advances in artificial intelligence, its application to the computational pathology field with the aim of supporting and providing a second opinion to the professional is of great interest. In this work, the inter-observer variability of a local dataset of 80 whole-slide images annotated by a team of 5 pathologists from the same group was analyzed at both area and label level. Four approaches were followed to train six different Convolutional Neural Network architectures, which were evaluated on the same dataset on which the inter-observer variability was analyzed. An inter-observer variability of 0.6946 κ was obtained, with 46% discrepancy in terms of area size of the annotations performed by the pathologists. The best trained models achieved 0.826±0.014κ on the test set when trained with data from the same source. The obtained results show that deep learning-based automatic diagnosis systems could help reduce the widely-known inter-observer variability that is present among pathologists and support them in their decision, serving as a second opinion or as a triage tool for medical centers.

Nowadays, the percentage of time that the population spends sitting has increased substantially due to the use of computers as the main tool for work or leisure and the increase in jobs with a high office workload. As a consequence, it is common to suffer musculoskeletal pain, mainly in the back, which can lead to both temporary and chronic damage. This pain is related to holding a posture during a prolonged period of sitting, usually in front of a computer. This work presents a IoT posture monitoring system while sitting. The system consists of a device equipped with Force Sensitive Resistors (FSR) that, placed on a chair seat, detects the points where the user exerts pressure when sitting. The system is complemented with a Machine Learning model based on Artificial Neural Networks, which was trained to recognize the neutral correct posture as well as the six most frequent postures that involve risk of damage to the locomotor system. In this study, data was collected from 12 participants for each of the seven positions considered, using the developed sensing device. Several neural network models were trained and evaluated in order to improve the classification effectiveness. Hold-Out technique was used to guide the training and evaluation process. The results achieved a mean accuracy of 81% by means of a model consisting of two hidden layers of 128 neurons each. These results demonstrate that is feasible to distinguish different sitting postures using few sensors allocated in the surface of a seat, which implies lower costs and less complexity of the system.

Monitoring animals’ behavior living in wild or semi-wild environments is a very interesting subject for biologists who work with them. The difficulty and cost of implanting electronic devices in this kind of animals suggest that these devices must be robust and have low power consumption to increase their battery life as much as possible. Designing a custom smart device that can detect multiple animal behaviors and that meets the mentioned restrictions presents a major challenge that is addressed in this work. We propose an edge-computing solution, which embeds an ANN in a microcontroller that collects data from an IMU sensor to detect three different horse gaits. All the computation is performed in the microcontroller to reduce the amount of data transmitted via wireless radio, since sending information is one of the most power-consuming tasks in this type of devices. Multiples ANNs were implemented and deployed in different microcontroller architectures in order to find the best balance between energy consumption and computing performance. The results show that the embedded networks obtain up to 97.96% ± 1.42% accuracy, achieving an energy efficiency of 450 Mops/s/watt.

Accurate and efficient classification of brain tumors, including gliomas, meningiomas, and pituitary adenomas, is critical for early diagnosis and treatment planning. Magnetic resonance imaging (MRI) is a key diagnostic tool, and deep learning models have shown promise in automating tumor classification. However, challenges remain in achieving high accuracy while maintaining interpretability for clinical use. This study explores the use of transfer learning with pre-trained architectures, including VGG16, DenseNet121, and Inception-ResNet-v2, to classify brain tumors from MRI images. An ensemble-based classifier was developed using a majority voting strategy to improve robustness. To enhance clinical applicability, explainability techniques such as Grad-CAM++ and Integrated Gradients were employed, allowing visualization of model decision-making. The ensemble model outperformed individual Convolutional Neural Network (CNN) architectures, achieving an accuracy of 86.17% in distinguishing gliomas, meningiomas, pituitary adenomas, and benign cases. Interpretability techniques provided heatmaps that identified key regions influencing model predictions, aligning with radiological features and enhancing trust in the results. The proposed ensemble-based deep learning framework improves the accuracy and interpretability of brain tumor classification from MRI images. By combining multiple CNN architectures and integrating explainability methods, this approach offers a more reliable and transparent diagnostic tool to support medical professionals in clinical decision-making.