Dr. Li Shen is a professor of Informatics | Radiology | Computer and Information Science at the University of Pennsylvania. He serves as the Associate Director for Bioinformatics at the Penn Institute for Biomedical Informatics (IBI), the Faculty Director of the IBI Bioinformatics Core, and Co-Director of the Penn Center For AI And Data Science For Integrated Diagnostics (AI2D). Dr. Shen obtained his Ph.D. degree in Computer Science from Dartmouth College. He is a pioneer in bioinformatics strategies for brain-wide genome-wide association studies to advance Alzheimer’s disease research. His research spans trustworthy AI/ML, biomedical and health informatics, NLP/LLMs, medical image computing, network science, and multi-omics and systems biology, with applications across complex disorders. He has authored over 435 peer-reviewed articles in these fields. Dr. Shen has served on a variety of scientific journal editorial boards, grant review committees, and organizing committees of professional meetings in medical image computing and biomedical informatics. He is a fellow of AIMBE | ACMI | AMIA, a distinguished member of ACM, and a distinguished contributor to the IEEE Computer Society.