Melanoma is one of the most dangerous skin cancers, leading to high mortality rates. Early detection and resection are two important steps to reduce mortality. Recently, several studies have applied artificial intelligence to facilitate binary skin cancer classification. However, the imbalance of the sensitivity and specificity metrics affects the overall performance of the models. To solve this problem, we propose an optimization for deep Convolutional Neural Network (CNN) combined with a change in the best model selection for this binary melanoma classification. Our research uses ISIC 2019, the latest and largest dataset consist of 17,302 skin lesion images for training and best model selection. The performance of the best models is analyzed based on the 10% data of ISIC 2019 dataset, then compared with the performance of dermatologists on 100 medical images of the MClass-D dataset. Our optimized deep CNN solves the underfitting problem and avoids overfitting. Our proposed best model selection method with an increase in Youden Index (YI) on both test-10 and MClass-D datasets also outperforms traditional methods. Moreover, our solution effectively outperformed 153 out of 157 dermatologists, which surpasses the current state-of-the-art solution by 17 dermatologists.

The development of foundation models for brain MRI depends critically on the scale, diversity, and consistency of available data, yet systematic assessments of these factors remain scarce. In this study, we analyze 54 publicly accessible brain MRI datasets encompassing over 538,031 scans to provide a structured, multi-level overview tailored to foundation model development. At the dataset level, we characterize modality composition, disease coverage, and dataset scale, revealing strong imbalances between large healthy cohorts and smaller clinical populations. At the image level, we quantify voxel spacing, orientation, and intensity distributions across 14 representative datasets, demonstrating substantial heterogeneity that can influence representation learning. We then perform a quantitative evaluation of preprocessing variability, examining how intensity normalization, bias field correction, skull stripping, spatial registration, and interpolation alter voxel statistics and geometry. While these steps improve within-dataset consistency, residual differences persist between datasets. Finally, a feature-space case study using a 3D DenseNet121 shows measurable residual covariate shift after standardized preprocessing, confirming that harmonization alone cannot eliminate inter-dataset bias. Together, these analyses provide a unified characterization of variability in public brain MRI resources and emphasize the need for preprocessing-aware and domain-adaptive strategies in the design of generalizable brain MRI foundation models.

Accurately predicting the progression of clinically isolated syndrome (CIS) to multiple sclerosis (MS) is crucial for early intervention and management. This study employs a range of machine learning models, including categorical boosting, extreme gradient boosting, light gradient boosting machine, random forest, support vector machine, and logistic regression, to classify CIS patients based on their likelihood of developing MS. Our best model achieves and demonstrates superior predictive accuracy of 0.9312, measured using the area under the curve metric. In addition, we apply explainability techniques to determine the most influential features driving the predictions, identifying which CISs are most indicative of MS progression. Furthermore, we explore feature interactions to detect relationships between features, providing a deeper understanding of the underlying mechanisms. The study utilizes public data from 273 CISs patients, offering significant contributions to the clinical management and early diagnosis of MS.

Histopathological examination of biopsy tissues is still utilized to diagnose and classify brain cancers today. The current approach is inconvenient, time-consuming, and prone to human mistake. These disadvantages emphasize the significance of establishing a fully automated deep learning-based system for classifying brain tumors. In this paper, we suggest an approach to improve the classification for four types of brain tumors by providing the classifier with segmentation as semantic features. 1,452 multi model magnetic resonance images from the Siberian Brain Tumor Dataset (SBT) are used for training, validation, and testing. The training and validation are implemented with our experimental simple convolutional neural network and a pre-trained VGG16. Best performed models are selected and tested on both SBT and the Brain Tumor Segmentation Challenge 2020 dataset (BraTS). The models with segmentation outperform all models without segmentation on the same dataset. We also found that, compare to a general purposed network such as VGG16, a simple convolutional neural network trained on a specific task have better generalization when tested with a public dataset.

Background: In this study, we examined the effectiveness of transfer learning in improving automatic segmentation of brain metastases on magnetic resonance imaging scans, with potential applications in preventive exams and remote diagnostics. Methods: We trained three deep learning models on a public dataset from the ASNR-MICCAI Brain Metastasis Challenge 2024, fine-tuned them on a small private dataset, and compared their performance to models trained from scratch. Results: Results showed that models using transfer learning performed better than scratch-trained models, though the improvement was not statistically substantial. The custom Tversky and Binary Cross-Entropy loss function helped manage class imbalance and reduce false negatives, limiting missed tumor regions. Medical experts noted that, while fine-tuned models worked well with larger, well-defined tumors, they struggled with tiny, scattered tumors in complex cases. Conclusions: This study highlights the potential of transfer learning and tailored loss functions in medical imaging, while also pointing out the models’ limitations in detecting very small tumors in challenging cases.