The collection and integration of all the known protein–protein physical interactions within a proteome framework are critical to allow proper exploration of the protein interaction networks that drive biological processes in cells at molecular level. APID Interactomes is a public resource of biological data (http://apid.dep.usal.es) that provides a comprehensive and curated collection of `protein interactomes’ for more than 1100 organisms, including 30 species with more than 500 interactions, derived from the integration of experimentally detected protein-to-protein physical interactions (PPIs). We have performed an update of APID database including a redefinition of several key properties of the PPIs to provide a more precise data integration and to avoid false duplicated records. This includes the unification of all the PPIs from five primary databases of molecular interactions (BioGRID, DIP, HPRD, IntAct and MINT), plus the information from two original systematic sources of human data and from experimentally resolved 3D structures (i.e. PDBs, Protein Data Bank files, where more than two distinct proteins have been identified). Thus, APID provides PPIs reported in published research articles (with traceable PMIDs) and detected by valid experimental interaction methods that give evidences about such protein interactions (following the `ontology and controlled vocabulary’: www.ebi.ac.uk/ols/ontologies/mi; developed by `HUPO PSI-MI’). Within this data mining framework, all interaction detection methods have been grouped into two main types: (i) `binary’ physical direct detection methods and (ii) `indirect’ methods. As a result of these redefinitions, APID provides unified protein interactomes including the specific `experimental evidences’ that support each PPI, indicating whether the interactions can be considered `binary’ (i.e. supported by at least one binary detection method) or not.

APID (Agile Protein Interactomes DataServer) is an interactive web server that provides unified generation and delivery of protein interactomes mapped to their respective proteomes. This resource is a new, fully redesigned server that includes a comprehensive collection of protein interactomes for more than 400 organisms (25 of which include more than 500 interactions) produced by the integration of only experimentally validated protein–protein physical interactions. For each protein–protein interaction (PPI) the server includes currently reported information about its experimental validation to allow selection and filtering at different quality levels. As a whole, it provides easy access to the interactomes from specific species and includes a global uniform compendium of 90,379 distinct proteins and 678,441 singular interactions. APID integrates and unifies PPIs from major primary databases of molecular interactions, from other specific repositories and also from experimentally resolved 3D structures of protein complexes where more than two proteins were identified. For this purpose, a collection of 8,388 structures were analyzed to identify specific PPIs. APID also includes a new graph tool (based on Cytoscape.js) for visualization and interactive analyses of PPI networks. The server does not require registration and it is freely available for use at http://apid.dep.usal.es.

Society and its leaders are increasingly aware of the need to fight climate change and CO₂ emissions in the search for sustainability. Maritime transport and ports are important sources of pollution and, while industry and the rest of the large-scale emitters have achieved considerable reductions in this area, “shipping” is still not advancing at the same rate, falling behind in this race. The aim of this article is to underline the importance of an early implementation of On-Shore Power Supply (OPS), Cold Ironing (CI) or Alternative Marine Power (AMP) by making a study of potentially avoidable CO₂ emissions from vessels docked (on the basis of the EPA [Environmental Protection Agency] and ENTEC [Environmental Engineering Consultancy, an environmental and engineering consultancy in UK] methods) close to urban areas in the Port of Santander (Spain). It is the first time potential reductions have been calculated for the last 11 years (2011–2021), distinguishing yearly emissions per type of vessel and providing real information to port authorities to prioritize the installation of this technological basis for the operation of piers/terminals to optimize investments and outcomes. In this case study, results demonstrate the outcomes of ROROs, ferries, and cruises being the first target of OPS implementation (reaching total of 37.95% of total emitted tons of CO₂ during the period of study). As a clear conclusion to this paper, the reader can understand the enormous and growing potential of this technology multiplied by the continuous development, increase and implementation of green energies.

Taking into account the increase in the emission of greenhouse gases produced by ships, during navigation and maneuvering in port, a direct consequence of the increase in maritime traffic, the international community has developed a broad set of regulations to limit such emissions. The installation in commercial ports of automatic mooring systems by means of vacuum suction cups, thus considerably reducing the time required to carry out ship mooring and unmooring maneuvers, is a factor that is considerably influencing the decrease in emissions of polluting gases in commercial ports with high traffic. The objective of the present work is to verify the influence of the use of the automatic mooring systems via vacuum suction cups on the emissions of polluting gases produced in the facilities destined to the traffic of container ships. To do this, two different calculation methods were used, Environmental Protection Agency and Environmental and Engineering Consultancy, to then compare the results of the two and thus obtain the reduction in emissions per twenty-foot equivalent unit in these terminals during mooring maneuvers. The paper concludes with a discussion on the values of the reductions in emissions obtained and the advantages of the installation of automatic mooring systems using vacuum suction cups in commercial ports located near population centers.

This paper presents a new approach for energetic analyses of traffic accidents against fixed road elements using close-range photogrammetry. The main contributions of the developed approach are related to the quality of the 3D photogrammetric models, which enable objective and accurate energetic analyses through the in-house tool CRASHMAP. As a result, security forces can reconstruct the accident in a simple and comprehensive way without requiring spreadsheets or external tools, and thus avoid the subjectivity and imprecisions of the traditional protocol. The tool has already been validated, and is being used by the Local Police of Salamanca (Salamanca, Spain) for the resolution of numerous accidents. In this paper, a real accident of a car against a fixed metallic pole is analysed, and significant discrepancies are obtained between the new approach and the traditional protocol of data acquisition regarding collision speed and absorbed energy.

Objective: This article develops and validates a new methodology and tool for rescue assistance in traffic accidents, with the aim of improving its efficiency and safety in the evacuation of people, reducing the number of victims in road accidents. Method: Different tests supported by professionals and experts have been designed under different circumstances and with different categories of damaged vehicles coming from real accidents and simulated trapped victims in order to calibrate and refine the proposed methodology and tool. Results: To validate this new approach, a tool called App_Rescue has been developed. This tool is based on the use of a computer system that allows an efficient access to the technical information of the vehicle and sanitary information of the common passengers. The time spent during rescue using the standard protocol and the proposed method was compared. Conclusion: This rescue assistance system allows us to make vital information accessible in posttrauma care services, improving the effectiveness of interventions by the emergency services, reducing the rescue time and therefore minimizing the consequences involved and the number of victims. This could often mean saving lives. In the different simulated rescue operations, the rescue time has been reduced an average of 14%.