Dr. Marcos Luiz Ferreira Neto
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Academic Career Length
6Years (2021-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications25 January 2022 in Hematology, Transfusion and Cell Therapy
Journal Article
MMMichelle Mendanha Mendonça
Michelle Mendanha MendonçaKCKellen Rosa da Cruz
Kellen Rosa da CruzDPDenise da Silva Pinheiro
Denise da Silva PinheiroGMGean Carlos Alves Moraes
Gean Carlos Alves MoraesMarcos Luiz Ferreira NetoCXCarlos Henrique Xavier
Carlos Henrique Xavier +5
The evolving COVID-19 pandemic became a hallmark in human history, not only by changing lifestyles, but also by enriching scientific knowledge on viral infection and its consequences. Although the management of cardiorespiratory changes is pivotal to a favorable prognosis during severe clinical findings, dysregulation of other systems caused by SARS-CoV-2 infection may imbalance erythrocyte dynamics, such as a bidirectional positive feedback loop pathophysiology. Recent evidence shows that SARS-CoV-2 is capable of affecting the genetics and dynamics of erythrocytes and this coexists with a non-homeostatic function of cardiovascular, respiratory and renal systems during COVID-19. In hypothesis, SARS-CoV-2-induced systematical alterations of erythrocytes dynamics would constitute a setpoint for COVID-19-related multiple organ failure syndrome and death. The present review covers the most frequent erythrocyte-related non-homeostatic findings during COVID-19 capable of providing mechanistic clues of SARS-CoV-2-induced infection and inspiring therapeutic-oriented scientific evidence.
19 January 2021 in Fundamental & Clinical Pharmacology
Journal Article
MMMichelle M. Mendonça
Michelle M. MendonçaACAmanda N. Costa
Amanda N. Costa
GMGean C.A. Moraes
Gean C.A. Moraes
GMGustavo M. Martins
Gustavo M. Martins
AAAline F. Almeida
Aline F. Almeida
CXCarlos Henrique Xavier
Carlos Henrique Xavier +11
Journal Article
Alberto Souza Sá FilhoJOJohn Ihayi Ogbu
John Ihayi OgbuAOAyobami J. Olusola
Ayobami J. OlusolaSASaheed Olanrewaju Afolabi
Saheed Olanrewaju Afolabi
Gustavo Rodrigues PedrinoJFJames Oluwagbamigbe Fajemiroye
James Oluwagbamigbe Fajemiroye +8
Plant essential oils (EOs) exhibit promising anxiolytic activity, but their application may be constrained by adverse motor effects arising from interactions with neural circuits controlling movement. Here, we investigated the anxiolytic-like effects and motor impairment liability of EOs from Pimenta pseudocaryophyllus, Melissa officinalis, Matricaria chamomilla, Lippia alba, Salvia rosmarinus, Ocimum basilicum, Spiranthera odoratissima, and Cymbopogon citratus, integrating computational target prediction with behavioral pharmacology. Prioritized EO constituents were subjected to target prediction, molecular docking, and 100-ns molecular dynamics simulations to identify molecular mechanisms potentially associated with motor impairment. Male and female Swiss mice received oral vehicle 10 mL/kg, EOs (10, 100, or 500 mg/kg) or diazepam (DZP 1 or 5 mg/kg), followed by the evaluation of anxiolytic-like behavior and motor coordination in the elevated plus maze and rotarod test, respectively. In silico analyses involving docking and molecular dynamics simulations of computationally prioritized EO constituents identified candidate targets within M1 and M2 receptors. All EOs exhibited anxiolytic-like activity at the intermediate dose. Motor impairment varied markedly among EOs. Integrating computational target prediction with behavioral assessment identified distinct motor liability profiles among EOs.
About Me
Full Professor, Department of Physiology, Institute of Biomedical Sciences, Federal University of Uberlândia (DEFIS/ICBIM/UFU), where he coordinates the Laboratory of Electrophysiology and Experimental Cardiovascular Physiology. He holds a Bachelor's degree in Physical Education from the Federal University of Uberlândia (UFU, 1998), and a Master's and Doctorate in Sciences from the Postgraduate Program in Pharmacology (Cardiovascular and Respiratory Physiology Discipline of the Department of Physiology) at the Federal University of São Paulo (UNIFESP, 1999 to 2006). He served as Coordinator of the Undergraduate Physical Education Program - Licentiate/Bachelor's (2011-2013) and Coordinator of Extension at the Institute of Biomedical Sciences (2017-2019). An effective member of the Brazilian Society of Physiology (SBFiS), he served as a member of the Fiscal Council (2020-2023) and the Scientific Dissemination Committee (2020-2021). He currently conducts research on: 1. Neuroendocrine systems and potential therapeutic routes in cardiometabolic pathophysiologies; 2. Genesis and/or treatment of arterial hypertension; 3. Neural and peripheral mechanisms involved in circulating volume and blood pressure adjustments; 4. Neural mechanisms involved in alert and defense behaviors; and 5. Osteogenic alterations and postpartum depression. 6. Identification of polymorphisms of ACE and ACE II enzymes and susceptibility to the development of cardiovascular diseases.