Synthesis and characterization of complexes of rhodium (III), chromium (III) and nickel (II) with polyaminopolycarboxylate type ligands, structural and computational studies, examination of biological activity of ligands and rhodium (III) complexes. Synthesis of rhodium(II) and ruthenium(II)-p-cymene complexes with heterocyclic ligands of imidazole, thiazole and isothiazole type, structural and computational research, characterization of synthesized complexes using X-Ray analysis, NMR, UV-Vis and IR spectra, testing of biological activity of ligands and complexes as well as their interactions with DNA and HSA molecules. Mechanochemical synthesis.