A Professor of Biochemistry whose research expertises involve cell signaling regulating cytoskeletons. A highlight of my work is that I found the myosin phosphatase regulator, named CPI-17 in 1995, and have been characterizing the signaling pathways in regulation of smooth muscle contraction at Hokkaido University, University of Virginia, Thomas Jefferson University and the current institution of Okayama University of Science. Myosin phosphorylation governs cell motility and it is tightly regulated through multiple pathways. To fully understand cytoskeletal regulation in smooth muscles, multi-disciplinary approach is used for interrogating signaling pathways at molecular, cellular, organ and animal levels.