Suzetrigine: Is This What We Have Been Waiting for or Just the Beginning?

Aim: This case series aimed to analyze the efficacy of a temporary peripheral nerve stimulation (PNS) device implanted for 60 days at 60 days post-explant for patients with non-surgical osteoarthri... Plain language summary Temporary peripheral nerve stimulation (PNS) is a treatment for patients with knee swelling and pain who can't get surgery. The authors studied temporary PNS to see if the pa...

Objective: To compare the efficacy of closed‐loop spinal cord stimulation (CL‐SCS) and dorsal root ganglion (DRG) stimulation in managing chronic cancer‐related pain.Material/Methods: A retrospective review was conducted with IRB exemption for four patients with cancer‐related pain who underwent combination stimulator trials. Patients were trialed with both CL‐SCS and DRG stimulation for 8–10 days, with assessments of pain relief, functional improvement, sleep improvement, pain medication changes, and overall satisfaction.Results: All four patients reported significant relief and functional improvement with both CL‐SCS and DRG stimulations. CL‐SCS provided a range of 12.9–19.6 million adjustments during the trial period. Neural dose was delivered at a median dose ratio of 1.35 and median dose accuracy of 4.9 μV. Patients 1–3 preferred CL‐SCS for paresthesia‐based stimulation, having the potential to expand pain coverage, full‐body MRI compatibility, and real‐time automated adjustment features. Patient 4 favored DRG for its ability to provide slightly greater relief, over one aspect of his pain area, despite having comparable coverage with CL‐SCS.Conclusions: The consistent and adaptable delivery of CL‐SCS may bridge the gap in efficacy that DRG therapy has held over traditional dorsal column stimulation for historically complex and focal conditions that suggests further investigation.

Objective: To examine how product popularity and pricing are associated with customer satisfaction across pain-relief device types on online e-commerce platforms. Methods: A cross-sectional study was conducted to analyze pain-relief products from Amazon and Best Buy. Data were collected via automated web scraping, verified, and categorized into 10 device types. Key variables including product names, prices, customer ratings, and review volumes were assessed in multivariable regression models. Results: A total of 378 distinct pain-relief products were analyzed. The median customer ratings for pain-relief devices varied significantly by type, ranging from 3.2 to 4.5 (p < 0.001). TENS units and cold/heat therapy packs achieved the highest median ratings of 4.5 (4.3– 4.6). In contrast, hand/arm massagers received the lowest median rating of 3.2 (2.2– 4.2). Pricing differences across device types were significant (p < 0.001), with neck stretchers being the least expensive (median: $29.99) and hand/arm massagers being the most expensive (median: $249.50). Discussion: Although price and the number of reviews were not significant predictors of customer ratings in multivariable regression models, significant interactions were observed between price and device type for hand/arm massagers (p < 0.001) and massage guns (p = 0.006). Additionally, significant interactions between the number of reviews and device type were observed for hand/arm massagers (p = 0.004). Conclusion: Although pricing and review quantity were not significant predictors of satisfaction for most devices, they did interact with specific categories such as hand/arm massagers and massage guns. These findings indicate that customer satisfaction is driven more by device-specific characteristics than by price or review volume.

Current Challenges and Potential Solutions for Targeted Drug Delivery (TDD) in Cancer Pain Management