Mario de Lucio

Dr. Mario de Lucio

Eli Lilly and Company, Indianapolis, Indiana, USA
orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 October 2021 in Computer Methods in Applied Mechanics and Engineering
Verified
Journal Article
Closed access
YLYu Leng
Yu Leng
MLMario de Lucio
Mario de Lucio
HGHector Gomez
Hector Gomez

1 January 2021 in Computer Methods in Applied Mechanics and Engineering
Verified
Journal Article
Closed access
MLMario de Lucio
Mario de Lucio
MBMiguel Bures
Miguel Bures
AAArezoo M. Ardekani
Arezoo M. Ardekani
PVPavlos P. Vlachos
Pavlos P. Vlachos
HGHector Gomez
Hector Gomez

9 December 2022 in Journal of the Mechanical Behavior of Biomedical Materials
Verified
Journal Article
Closed access
MLMario de Lucio
Mario de Lucio
YLYu Leng
Yu Leng
AHAtharva Hans
Atharva Hans
IBIlias Bilionis
Ilias Bilionis
MBMelissa Brindise
Melissa Brindise
HGHector Gomez
Hector Gomez

22 October 2020 in Computer Methods in Biomechanics and Biomedical Engineering
Verified
Journal Article
Closed access
MLMario de Lucio
Mario de Lucio
MGMarcos Fernández García
Marcos Fernández García
JGJacobo Díaz García
Jacobo Díaz García
LRLuis Esteban Romera Rodríguez
Luis Esteban Romera Rodríguez
FMFrancisco Álvarez Marcos
Francisco Álvarez Marcos
Layer-specific experimental data for human aortic tissue suggest that, in aged arteries and arteries with non-atherosclerotic intimal thickening, the innermost layer of the aorta increases significantly its stiffness and thickness, becoming load-bearing. However, there are very few computational studies of abdominal aortic aneurysms (AAAs) that take into account the mechanical contribution of the three layers that comprise the aneurysmal tissue. In this paper, a three-layered finite element model is proposed from the simplest uniaxial stress state to geometrically parametrized models of AAAs with different asymmetry values. Comparisons are made between a three-layered artery wall and a mono-layered intact artery, which represents the complex behavior of the aggregate adventitia-media-intima in a single layer with averaged mechanical properties. Likewise, the response of our idealized geometries is compared with similar experimental and numerical models. Finally, the mechanical contributions of adventitia, media and intima are analyzed for the three-layered aneurysms through the evaluation of the mean stress absorption percentage. Results show the relevance and necessity of considering the inclusion of tunica intima in multi-layered models of AAAs for getting accurate results in terms of peak wall stresses and displacements.

1 August 2023 in Biomechanics and Modeling in Mechanobiology
Verified
Journal Article
Closed access
PDF file
MLMario de Lucio
Mario de Lucio
YLYu Leng
Yu Leng
HWHao Wang
Hao Wang
AAArezoo Ardekani
Arezoo Ardekani
PVPavlos P. Vlachos
Pavlos P. Vlachos
HGHector Gomez
Hector Gomez

10 July 2024 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
MLMario de Lucio
Mario de Lucio
YLYu Leng
Yu Leng
HWHao Wang
Hao Wang
PVPavlos P. Vlachos
Pavlos P. Vlachos
HGHector Gomez
Hector Gomez