Dr. Mingji Jin
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China;
+1
Mingji Jin is mainly engaged in pharmaceutical research, and...
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Academic Career Length
16Years (2011-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications5 April 2024 in Journal of Controlled Release
Journal Article
SWShuangqing Wang
Shuangqing Wang
YLYanhong Liu
Yanhong Liu
XWXusheng Wang
Xusheng Wang
LCLiqing Chen
Liqing Chen
WHWei Huang
Wei Huang
Mingji Jin +4
24 February 2022 in Biomaterials
Journal Article
YHYan Hou
Yan HouJJJingzhe Jin
Jingzhe Jin
HDHongxia Duan
Hongxia Duan
CLChao Liu
Chao Liu
LCLiqing Chen
Liqing Chen
Mingji Jin +2
Journal Article
WJWenyu Jin
Wenyu Jin
Wei HuangLCLiqing Chen
Liqing ChenMingji JinQWQiming Wang
Qiming WangZJZhehu Jin
Zhehu Jin +1
Atopic dermatitis (AD) is a chronic recurrent skin disease dominated by T-helper 2 inflammation. Momelotinib (MMB) is a novel JAK1/JAK2 inhibitor suppressing the signal transduction of multiple pro-inflammatory cytokines. Recent studies indicated that JAK inhibitor could play a therapeutic role in AD disease. In this study, we evaluated the efficacy of MMB as a novel JAK1/JAK2 inhibitor in DNCB-induced AD mice and TSLP-activated dendritic cells. Our data showed that topical application of MMB reduced the skin severity scores and total serum IgE levels, and alleviated the histological indexes including epidermal thickness measurement and mast cell number. Also, it was demonstrated that MMB down-regulated the mRNA expression of IL-4, IL-5, IFN-γ and TSLP, and inhibited the phosphorylation of STAT1, STAT3 and STAT5 in skin lesions. Moreover, MMB reduced the expression of CD80, CD86, MHCII and mRNA of OX40L in TSLP-activated dendritic cells. In general, our study suggests that MMB can improve the symptoms of AD and topical application of MMB can become a promising new therapy strategy for AD.
Journal Article
NWNuoya Wang
Nuoya WangLCLiqing Chen
Liqing ChenWei HuangZGZhonggao Gao
Zhonggao GaoMingji JinColorectal cancer (CRC) is a common malignant tumor, and traditional treatments include surgical resection and radiotherapy. However, local recurrence, distal metastasis, and intestinal obstruction are significant problems. Oral nano-formulation is a promising treatment strategy for CRC. This study introduces physiological and environmental factors, the main challenges of CRC treatment, and the need for a novel oral colon-targeted drug delivery system (OCDDS). This study reviews the research progress of controlled-release, responsive, magnetic, targeted, and other oral nano-formulations in the direction of CRC treatment, in addition to the advantages of oral colon-targeted nano-formulations and concerns about the oral delivery of related therapeutic agents to inspire related research.
10 May 2014 in BMC Cancer
Journal Article
YLYunfei Li
Yunfei LiMingji JinSSShuai Shao
Shuai ShaoWei HuangFYFeifei Yang
Feifei YangZGZhonggao Gao
Zhonggao Gao +3
The small size of ultra-small nanoparticles makes them suitable for lymphatic delivery, and many recent studies have examined their role in anti-metastasis therapy. However, the anti-metastatic efficacy of small-sized nanocarriers loaded with taxanes such as docetaxel has not yet been investigated in malignant breast cancer.
Journal Article
HZHeming Zhao
Heming ZhaoLGLiming Gong
Liming GongHWHao Wu
Hao WuCLChao Liu
Chao LiuYLYanhong Liu
Yanhong LiuWei Huang +6
Prostate cancer (PC) is one of the common malignant tumors of the male genitourinary system. Here, we constructed PTX@ZIF-8, which is a metal-organic-framework-encapsulated drug delivery nanoparticle with paclitaxel (PTX) as a model drug, and further modified the synthesized peptide dimer (Di-PEG2000-COOH) onto the surface of PTX@ZIF-8 to prepare a nanotargeted drug delivery system (Di-PEG@PTX@ZIF-8) for the treatment of prostate cancer. This study investigated the morphology, particle size distribution, zeta potential, drug loading, encapsulation rate, stability, in vitro release behavior, and cytotoxicity of this targeted drug delivery system, and explored the uptake of Di-PEG@PTX@ZIF-8 by human prostate cancer Lncap cells at the in vitro cellular level, as well as the proliferation inhibition and promotion of apoptosis of Lncap cells by the composite nanoparticles. The results suggest that Di-PEG@PTX@ZIF-8, as a zeolitic imidazolate frameworks-8-loaded paclitaxel nanoparticle, has promising potential for the treatment of prostate cancer, which may provide a novel strategy for the delivery system targeting prostate cancer.
About Me
Prof. Dr. Mingji Jin is an Associate Researcher at the State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences, and Peking Union Medical College. She is mainly engaged in pharmaceutical research, with the research direction of nano-delivery systems. She has presided over the National Natural Science Foundation of China Youth Fund and the Union Medical College Graduate Student Innovation Fund; and participated in more than 10 research projects such as the "Major New Drug Creation" of the National Science and Technology Major Special Fund, the National Natural Science Foundation of China, and the Beijing Natural Science Foundation project. She published 35 SCI papers and 11 core journal papers, applied for 6 invention patents, and obtained 3 authorized patents. Starting in 2020, she has participated in the teaching of the "Integrated Clinical Pharmacotherapeutics" course and assisted the project leader in training many doctoral students and graduate students. In November 2014, she won the second prize of the Jilin Provincial Science and Technology Award.