Decarbonisation of the iron and steel (I&S) industry is crucial in the efforts to meet the EU GHG emission reduction objectives in 2030 … 2050. Promoting decarbonisation in this sector will necessarily require the identification, development, and diffusion of breakthrough technologies for I&S production.

In naturally occurring bovine mastitis, effects of infection depend on the host inflammatory response, including the effects of secreted cytokines. Knowledge about the inflammatory and regulatory cytokines in milk cells of free-stall barn dairy cows and in naturally occurring mastitis is lacking as most studies focus on induced mastitis. Hereby, the aim of the study was to determine inflammatory and regulatory cytokines in the milk of dairy cows with subclinical and clinical mastitis. The following examinations of milk samples were performed: differential counting of somatic cells (SCC), bacteriological examination, and immunocytochemical analysis. Mean SCC increased in subclinical and clinical mastitis cases. The number of pathogenic mastitis-causing bacteria on plates increased in subclinical mastitis cases but decreased in clinical mastitis. The inflammatory and regulatory markers in the milk cells of healthy cows showed the highest mean cell numbers (%). In mastitis cases, immunoreactivity was more pronounced for IL-4, IL-6, IL-12, IL-13, IL-17A, TNF-α, and IFN-γ. Data about subclinical and clinical mastitis demonstrate inflammatory responses to intramammary infection driven by IL-1α, IL-4, and IL-17A. Moreover, the host defense response in mastitis is characterized by continuation or resolution of initial inflammation. IL-12 and INF-γ immunoreactivity was recognized to differ mastitis cases from the relative health status.

Between 2018 and 2023 the penetration rate of electricity smart meters in the European Union (EU) is expected to grow from approximately 44% to 71%. The unprecedently rapid development of smart metering (SM) as an ICT-enabled technological novelty is progressing in a complex, multi-actor innovation system, which is strongly driven by EU-level institutions and policies. This paper presents the comprehensive Technology Innovation System (TIS) analysis of electricity SM development in the EU, with a focus placed on regulatory aspects. The article identifies the key elements of the SM innovation system (technologies and infrastructures; actors and networks; institutions and policies) and characterises their interaction based on an in-depth desk research and a critical assessment of regulations, statistics and primary and grey literature sources (e.g., market reports). The main enablers and barriers for EU-level SM TIS development are studied. The major driving force for EU-level SM TIS is the clear, yet evolving vision of EU-level actors for the SM deployment, founded on the grounds of energy conservation and empowerment of customers. On the other hand, the major inhibitor is the insufficient regulatory framework for roll-outs at the level of a Member State, which does not fully ensure interoperability, data protection and security standards or organisational effectiveness.