Dissimilar welds impose a challenge to the engineers concerned with the structural integrity assessment of these joints. This is because of the highly inhomogeneous nature of these joints in terms of their microstructure, mechanical, thermal, and fracture properties. Fracture mechanics-based concepts cannot be directly used because of the problems associated with the definition of a suitable crack-tip loading parameter such as J-integral crack tip opening displacement (CTOD), etc. Again, depending upon the location of initial crack (i.e. base, weld, buttering, different interfaces, etc.), further crack propagation can occur in any material. The objective of the current work is to use micro-mechanical models of ductile fracture for initiation and propagation of cracks in the bimetallic welds. The authors have developed a finite element formulation that incorporates the porous plasticity yield function due to Gurson—Tvergaard—Needleman and utilized it here for the analysis. Experiments have been conducted at MPA Stuttgart using single edge-notched bend (SEB) specimens with cracks at different locations of the joint. The micro-mechanical (Gurson) parameters of four different materials (i.e. ferrite, austenite, buttering, and weld) have been determined individually by simulation of fracture resistance behaviour of SEB specimens and comparing the simulated results with those of the experiment. In order to demonstrate the effectiveness of the damage model in predicting the crack growth in the actual bimetallic-welded specimen, simulation of two SEB specimens (with initial crack at ferrite—buttering and buttering—weld interface) has been carried out. The simulated fracture resistance behaviour compares well with those of the experiment.