Mohamed Azzouzi

Prof. Mohamed Azzouzi

EST Khenifra University of Sultan My Slimane, Khénifra, Béni Mellal-Khénifra, Morocco
orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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13 July 2022 in Journal of Molecular Liquids
Verified
Journal Article
Closed access
WALID DAOUDIWALID DAOUDI
WALID DAOUDI
AAAbdelmalik El Aatiaoui
Abdelmalik El Aatiaoui
NFNoureddine Falil
Noureddine Falil
Mohamed AzzouziMohamed Azzouzi
Mohamed Azzouzi
Avni BerishaAvni Berisha
Avni Berisha
AOAdyl Oussaid
Adyl Oussaid

25 January 2023 in Materials Science and Engineering: B
Verified
Journal Article
Closed access
WALID DAOUDIWALID DAOUDI
WALID DAOUDI
Mohamed AzzouziMohamed Azzouzi
Mohamed Azzouzi
ODOmar Dagdag
Omar Dagdag
ABAli El Boutaybi
Ali El Boutaybi
Avni BerishaAvni Berisha
Avni Berisha
AAAbdelmalik El Aatiaoui
Abdelmalik El Aatiaoui

15 December 2023 in ACS Omega
Verified
Journal Article
Open access
Mohamed AzzouziMohamed Azzouzi
Mohamed Azzouzi
OAOmar Azougagh
Omar Azougagh
AOAbderrahim Ait Ouchaoui
Abderrahim Ait Ouchaoui
SHSalah Eddine El Hadad
Salah Eddine El Hadad
SMStéphane Mazières
Stéphane Mazières
AOAdyl Oussaid
Adyl Oussaid
In this study, (E)-2-phenyl-N-(thiophen-2-ylmethylene)imidazo[1,2-a]pyrimidin-3-amine (3) is synthesized, and detailed spectral characterizations using 1H NMR, 13C NMR, mass, and Fourier transform infrared (FT-IR) spectroscopy were performed. The optimized geometry was computed using the density functional theory method at the B3LYP/6-311++G(d,p) basis set. The theoretical FT-IR and NMR (1H and 13C) analysis are agreed to validate the structural assignment made for (3). Frontier molecular orbitals, molecular electrostatic potential, Mulliken atomic charge, electron localization function, localized orbital locator, natural bond orbital, nonlinear optical, Fukui functions, and quantum theory of atoms in molecules analyses are undertaken and meticulously interpreted, providing profound insights into the molecular nature and behaviors. In addition, ADMET and drug-likeness studies were carried out and investigated. Furthermore, molecular docking and molecular dynamics simulations have been studied, indicating that this is an ideal molecule to develop as a potential vascular endothelial growth factor receptor-2 inhibitor.

16 April 2025 in RSC Advances
Verified
Journal Article
Open access
PDF file
Mohamed AzzouziMohamed Azzouzi
Mohamed Azzouzi
WDWalid Daoudi
Walid Daoudi
ODOmar DAGDAG
Omar DAGDAG
Avni BerishaAvni Berisha
Avni Berisha
HKHansang Kim
Hansang Kim
AOAdyl Oussaid
Adyl Oussaid
Two novel imidazo[1,2- a ]pyrimidine-Schiff base derivatives were synthesized and evaluated as efficient, eco-friendly corrosion inhibitors for mild steel in acidic media using electrochemical, theoretical, and toxicity assessments.

7 April 2023 in Journal of Molecular Structure
Verified
Journal Article
Closed access
Mohamed AzzouziMohamed Azzouzi
Mohamed Azzouzi
ZOZainab El Ouafi
Zainab El Ouafi
OAOmar Azougagh
Omar Azougagh
WALID DAOUDIWALID DAOUDI
WALID DAOUDI
HGHassan Ghazal
Hassan Ghazal
AOAdyl Oussaid
Adyl Oussaid

16 May 2024 in Heliyon
Verified
Journal Article
Open access
AHAbdeljalil Hamdi
Abdeljalil Hamdi
WALID DAOUDIWALID DAOUDI
WALID DAOUDI
MAMohamed Aaddouz
Mohamed Aaddouz
Mohamed AzzouziMohamed Azzouzi
Mohamed Azzouzi
HAHassan Amhamdi
Hassan Amhamdi
MAM'HAmed Ahari
M'HAmed Ahari
The imidazole nucleus represents a significant group of heterocyclic molecules with diverse significance in the modern world due to its exploration potential and various pharmacological applications. The relevance of imidazole and its derivatives has gained popularity in recent years, especially in the production of commercial drugs and the treatment of various conditions. The imidazole nucleus is present in many natural compounds and widely distributed in essential amino acids, such as l-histidine, whose derivatives exhibit powerful pharmacological properties. In this review, we delve into the historical timeline and development of synthetic pathways for tri- and tetra-substituted imidazoles used in the renowned Radziszewski reaction. Furthermore, we explore various bacteriological applications documented in the literature, as well as current advances in preclinical approaches to imidazole-based drug discovery. Tri- or tetra-substituted imidazole derivatives show strong potential for new synthesis methods, such as reflux or microwave, as well as various biological activities.