My research focuses on the immunobiology of tissue-resident macrophages and their roles in inflammation, regeneration, fibrosis, and in renal diseases. I am particularly interested in chemokine-receptor signaling networks, especially the CX3CL1-CX3CR1 axis, as key regulators of macrophage longevity, niche maintenance, immune-metabolic programming, and tissue repair. My work integrates transgenic mouse models, lineage tracing, single-cell transcriptomics, and in vivo ablation systems to define how macrophage-epithelial and macrophage-stromal interactions shape organ homeostasis and pathological remodeling in the kidney and heart. Academically, I pursue interdisciplinary approaches that bridge innate immunity, systems immunology, and translational science, with the goal of identifying immune pathways that can be therapeutically targeted to promote regeneration while limiting fibrosis and chronic inflammation. My broader interests include host-pathogen interactions, complement biology, and immune-mediated tissue injury, particularly in viral infections and cardiovascular disease. Long-term, my academic objective is to develop mechanistic frameworks for immune-regulated tissue repair and to translate these insights into immunomodulatory strategies for inflammatory, fibrotic, and degenerative diseases.