In an era where sustainability and efficient resource utilization are paramount, the closed-loop supply chain (CLSC) emerges as a critical approach, particularly in the context of perishable goods. The perishability of products adds a layer of complexity to supply chain management, necessitating innovative strategies for maximizing product life and minimizing waste. This comprehensive review article delves into the integration of perishable products within the framework of CLSC. The study thoroughly examines existing research to identify gaps and outline future research directions. It emphasizes the unique challenges and complexities of managing perishable goods, a crucial but often overlooked component in sustainable supply chain practices. The review highlights the balance between efficiency and sustainability, underscoring the importance of reverse logistics and circular economy principles in enhancing supply chain resilience. By synthesizing various methodologies and findings, the article presents a holistic view of the current state of perishable product management in CLSCs, offering valuable insights for academia and industry practitioners. The study not only contributes to the theoretical understanding of CLSCs, but also proposes practical approaches for their optimization, aligning with broader sustainability goals.