The performance of photovoltaic (PV) solar panels is dependent on certain factors, such as dust effects. Even though Palestine’s energy issues are well-known, no research has been undertaken on the soiling effect on solar energy generation in Palestine’s climatic circumstances. The study’s findings can aid Palestine’s efforts to achieve long-term energy sustainability and solar energy use. Outdoor research was conducted in Tulkarm, Palestine, to explore the impact of dust on PV systems. The current study examined the impact of dust accumulation based on the Mediterranean climate. To accomplish this, a one-year experiment was conducted from 1 January to 31 December 2021. An 85-kW PV power plant at Tulkarm was utilized in the study. Knowing the efficiency reduction over time will aid in minimizing cleaning expenses by selecting the most appropriate cleaning interval. The results concluded that in January, February, November, and December, there will be a two-month cleaning period, monthly cleaning in March and October, as well as two weeks of cleaning in April and May. It may also be concluded that the plant should be cleaned weekly throughout the months of June, July, August, and September. This recommendation is necessary to maintain the PV panel plant operating at peak efficiency.