Duc-Khanh Nguyen

Mr. Duc-Khanh Nguyen

Yuan Ze University
orcid

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Duc-Khanh NguyenDuc-Khanh Nguyen
Duc-Khanh Nguyen
CLChung-Hsien Lan
Chung-Hsien Lan
CCChien-Lung Chan
Chien-Lung Chan
With the development of information and technology, especially with the boom in big data, healthcare support systems are becoming much better. Patient data can be collected, retrieved, and stored in real time. These data are valuable and meaningful for monitoring, diagnosing, and further applications in data analysis and decision-making. Essentially, the data can be divided into three types, namely, statistical, image-based, and sequential data. Each type has a different method of retrieval, processing, and deployment. Additionally, the application of machine learning (ML) and deep learning (DL) in healthcare support systems is growing more rapidly than ever. Numerous high-performance architectures are proposed to optimize decision-making. As reliability and stability are the most important factors in the healthcare support system, enhancing the predicted performance and maintaining the stability of the model are always the top priority. The main idea of our study comes from ensemble techniques. Numerous studies and data science competitions show that by combining several weak models into one, ensemble models can attain outstanding performance and reliability. We propose three deep ensemble learning (DEL) approaches, each with stable and reliable performance, that are workable on the above-mentioned data types. These are deep-stacked generalization ensemble learning, gradient deep learning boosting, and deep aggregation learning. The experiment results show that our proposed approaches achieve more vigorous and reliable performance than traditional ML and DL techniques on statistical, image-based, and sequential benchmark datasets. In particular, on the Heart Disease UCI dataset, representing the statistical type, the gradient deep learning boosting approach dominates the others with accuracy, recall, F1-score, Matthews correlation coefficient, and area under the curve values of 0.87, 0.81, 0.83, 0.73, and 0.91, respectively. On the X-ray dataset, representing the image-based type, the deep aggregation learning approach shows the highest performance with values of 0.91, 0.97, 0.93, 0.80, and 0.94, respectively. On the Depresjon dataset, representing the sequence type, the deep-stacked generalization ensemble learning approach outperforms the others with values of 0.91, 0.84, 0.86, 0.8, and 0.94, respectively. Overall, we conclude that applying DL models using our proposed approaches is a promising method for the healthcare support system to enhance prediction and diagnosis performance. Furthermore, our study reveals that these approaches are flexible and easy to apply to achieve optimal performance.

24 May 2021
Verified
Conference Paper
Open access
Duc-Khanh NguyenDuc-Khanh Nguyen
Duc-Khanh Nguyen
CCChien-Lung Chan
Chien-Lung Chan
ALAi-Hsien Adams Li
Ai-Hsien Adams Li
DPDinh-Van Phan
Dinh-Van Phan
In the modern world, mental health disorder is one of the serious problems for every nation around the globe, especially in this Covid-19 pandemic period. These illnesses affect not only patient's mental health but also physical health, thus, reduce productivity and quality of human work. Mental health disorder is complex and also takes many forms. In this study, we pay attention to depression (unipolar and bipolar) illness. We conducted our experiment on the open dataset named Depresjon, which was collected from activity motion signals on wearable devices of 32 healthy people and 23 depressed (unipolar and bipolar) patients over several days in a row with a total of 814 samples. Firstly, we did the preprocessing data step in order to make the dataset fitting the DL model input. After that, we deployed many individual DL models to make the first predictions. Next, we generated Deep Stacked Generalization Ensemble Learning (DeSGEL) models which were able to learn how to make the best combination of predictions from previous individual well-trained models. Finally, we made a comparison among the individual and the proposed DeSGEL models. The results showed that the DeSGEL models had outperformed other corresponding individual models. Specifically, among the individual models, VGG16 had the best performance. However, the DeSGEL Resnet based showed an extremely outstanding performance over other individual and ensemble DL models. In detail, these models had Accuracy, Precision, Sensitivity, Specification, F1 score, MCC and AUC of 0.94, 0.91, 0.89, 0.96, 0.90, 0.85 and 0.92 respectively for Individual VGG16 model, and 0.96, 0.96, 0.92, 0.98, 0.94, 0.91 and 0.95 respectively for the DeSGEL Resnet based model. We found that applying Deep learning, especially DeSGEL models using activity motion signal data from wearable devices could be a prospective direction for the early diagnosis of mental health disorders.

1 October 2022 in Health Informatics Journal
Verified
Journal Article
Open access
Duc-Khanh NguyenDuc-Khanh Nguyen
Duc-Khanh Nguyen
CCChien-Lung Chan
Chien-Lung Chan
ALAi-Hsien Adams Li
Ai-Hsien Adams Li
DPDinh-Van Phan
Dinh-Van Phan
CLChung-Hsien Lan
Chung-Hsien Lan
In the modern world, with so much inherent stress, mental health disorders (MHDs) are becoming more common in every country around the globe, causing a significant burden on society and patients’ families. MHDs come in many forms with various severities of symptoms and differing periods of suffering, and as a result it is difficult to differentiate between them and simple to confuse them with each other. Therefore, we propose a support system that employs deep learning (DL) with wearable device data to provide physicians with an objective reference resource by which to make differential diagnoses and plan treatment. We conducted experiments on open datasets containing activity motion signal data from wearable devices to identify schizophrenia and mood disorders (bipolar and unipolar), the datasets being named Psykose and Depresjon. The results showed that, in both workflow approaches, the proposed framework performed well in comparison with the traditional machine learning (ML) and DL methods. We concluded that applying DL models using activity motion signal data from wearable devices represents a prospective objective support system for MHD differentiation with a good performance.

14 August 2020
Verified
Conference Paper
Open access
Duc-Khanh NguyenDuc-Khanh Nguyen
Duc-Khanh Nguyen
Span>Sleep is not only very important for physical health but also the mental health of human, that was addressed by many previous studies. Today, with the development of technology, which opens in the application for improving quality of sleep, such as wearable devices, artificial intelligence, neural network. In this study, we applied deep learning (DL) neural networks and smart wearable devices to predict the quality of sleep. The data was collected on students (mean age = 20.79) during 106 days by Fitbit Charge HR™ device. The results showed DL models could predict sleep quality base on physical activities in awake time.

28 July 2021 in Briefings in Bioinformatics
Verified
Journal Article
Closed access
PDF file
TNTrinh-Trung-Duong Nguyen
Trinh-Trung-Duong Nguyen
Duc-Khanh NguyenDuc-Khanh Nguyen
Duc-Khanh Nguyen
YOYu-Yen Ou
Yu-Yen Ou
Since 2015, a fast growing number of deep learning–based methods have been proposed for protein–ligand binding site prediction and many have achieved promising performance. These methods, however, neglect the imbalanced nature of binding site prediction problems. Traditional data-based approaches for handling data imbalance employ linear interpolation of minority class samples. Such approaches may not be fully exploited by deep neural networks on downstream tasks. We present a novel technique for balancing input classes by developing a deep neural network–based variational autoencoder (VAE) that aims to learn important attributes of the minority classes concerning nonlinear combinations. After learning, the trained VAE was used to generate new minority class samples that were later added to the original data to create a balanced dataset. Finally, a convolutional neural network was used for classification, for which we assumed that the nonlinearity could be fully integrated. As a case study, we applied our method to the identification of FAD- and FMN-binding sites of electron transport proteins. Compared with the best classifiers that use traditional machine learning algorithms, our models obtained a great improvement on sensitivity while maintaining similar or higher levels of accuracy and specificity. We also demonstrate that our method is better than other data imbalance handling techniques, such as SMOTE, ADASYN, and class weight adjustment. Additionally, our models also outperform existing predictors in predicting the same binding types. Our method is general and can be applied to other data types for prediction problems with moderate-to-heavy data imbalances.

6 September 2024
Verified
Conference Paper
Open access
Duc-Khanh NguyenDuc-Khanh Nguyen
Duc-Khanh Nguyen
ALAi-Hsien Adams Li
Ai-Hsien Adams Li
YLYen-Jun Lai
Yen-Jun Lai
YCYen-Ling Chiu
Yen-Ling Chiu
PVPhan Dinh Van
Phan Dinh Van
CCChien-Lung Chan
Chien-Lung Chan
This study explores the feasibility of deep learning for classifying nodule neoplasms, analyzing their performance on two openly available datasets, LUNGx SPIE, and LIDC-IDRI. These datasets offer valuable diversity in image quantity, quality, and malignancy annotation methodologies, posing a real-world challenge for effective model development. To handle the disparities in these diverse datasets, we aim to develop a robust classification model trained using federated learning. This decentralized approach allows model training across datasets without sharing patient data, preserving privacy and overcoming data fragmentation. Our experiments demonstrate that federated learning enables the development of a robust and superior deep learning model compared to individual models trained on limited data. This combination of deep learning, and federated learning holds immense promise for nodule neoplasm classification and can significantly improve patient care and outcomes.