My research focuses on understanding the molecular genetics of inherited retinal diseases and developing therapies to treat these diseases. Our work has been instrumental in discovering the important role of nuclear hormone receptor genes in modulating retinal diseases. These genes function to maintain a healthy retina and regulate neuroprotection, phototransduction, oxidative stress, immunity, and lipid metabolism. I discovered that Nr2e3 is associated with human retinal degeneration and determined the role of Nr2e3 in the retina and studying the rd7 mice. My laboratory has identified several genetic modifier alleles that are able to ameliorate or attenuate degeneration in many models of retinal disease.