Thanh-Sang Nguyen’s research focuses on metabolomics and mass spectrometry-based investigation of bioactive natural products from plant, microbial, and food sources. His expertise includes LC-MS/MS data processing, feature-based molecular networking, spectral similarity analysis, and compound annotation using computational tools. His research aims to identify and prioritize diverse bioactive metabolites, including saponins, flavonoids, ginsenosides, and antimicrobial peptides. He also works on functional food evaluation and fermentation-derived bioactive compounds, with particular interest in fermentation stress responses and metabolomic-based approaches that link chemical composition with biological activity and microbial physiology.