Career choice has a pivotal role in college students’ life planning. In the past, professional career appraisers used questionnaires or diagnoses to quantify the factors potentially influencing career choices. However, due to the complexity of each person’s goals and ideas, it is difficult to properly forecast their career choices. Recent evidence suggests that we could use students’ behavioral data to predict their career choices. Based on the simple premise that the most remarkable characteristics of classes are reflected by the main samples of a category, we propose a model called the Approach Cluster Centers Based On XGBOOST (ACCBOX) model to predict students’ career choices. The experimental results of predicting students’ career choices clearly demonstrate the superiority of our method compared to the existing state-of-the-art techniques by evaluating on 13 M behavioral data of over four thousand students.