PhD. Raúl J. Delgado-Macuil is position in the Nanobiotechnology and Biosensors Laboratory in Centro de Investigación en Biotecnología Aplicada of the Instituto Politécnico Nacional, México. He completed his PhD studies in the INAOE México. He recently led the projects “Generation of optical biosensors for heavy metal determination in water and biologic matrix from La Paz BCS lagoon” and “Develop of optical biosensors in SiO2 matrices, for the determination of enzyme temporal expression of IL6 and IL10 by ischemic global event in rat”. He has published 91 papers in various journals and 10 book chapters, as serves as a reviewer for several international journals. His teaching disciplines include, optical biosensors systems, spectroscopic techniques and multivariable methods, His research topics mainly include: optical biosensors, chemometric analysis, infrared and Raman spectroscopies.