Prof. Giovannoni, Associate Professor of Genetics at Department of Biology, University of Pisa, focused his research activity mainly on the production and characterization of experimental in in vitro and in vivo models for human diseases. His activity, throughout the years, has allowed him to develop a profound knowledge on several expression and genetic engineering systems, both in vitro and in vivo, including multi-cistronic expression vectors and CRISPR-Cas9 models. The investigation of pathogenesis of human diseases in experimental models has been carried out in the following collaborative projects: design and development of innovative oral drug delivery system, based on plant biotechnologies and engineering, for the treatment of atherosclerosis and inflammatory disorders; study of hereditary neuromuscular diseases, channelopathies and epilepsy and hereditary ataxia (SCA1) in in vitro and in vivo models; study of adenosine and extracellular nucleotide metabolism in the molecular mechanisms of cytoprotection against inflammatory stimuli and oxidative stress; study of molecular and diagnostic markers in cancer biology; study of novel therapeutic approaches in gliomas and in breast cancer; study of the effects of local and systemic inflammation induced by hypercholesterolemic diet in pre-clinical models of atherosclerosis.
Research Keywords & Expertise
Drug Delivery
Genetic Engineering
Genetics
Biomarker
Cancer Drug Resistance
Biotechnology and mole...
Fingerprints
33%
Genetics
13%
Genetic Engineering
5%
Biomarker
Short Biography
Prof. Giovannoni, Associate Professor of Genetics at Department of Biology, University of Pisa, focused his research activity mainly on the production and characterization of experimental in in vitro and in vivo models for human diseases. His activity, throughout the years, has allowed him to develop a profound knowledge on several expression and genetic engineering systems, both in vitro and in vivo, including multi-cistronic expression vectors and CRISPR-Cas9 models. The investigation of pathogenesis of human diseases in experimental models has been carried out in the following collaborative projects: design and development of innovative oral drug delivery system, based on plant biotechnologies and engineering, for the treatment of atherosclerosis and inflammatory disorders; study of hereditary neuromuscular diseases, channelopathies and epilepsy and hereditary ataxia (SCA1) in in vitro and in vivo models; study of adenosine and extracellular nucleotide metabolism in the molecular mechanisms of cytoprotection against inflammatory stimuli and oxidative stress; study of molecular and diagnostic markers in cancer biology; study of novel therapeutic approaches in gliomas and in breast cancer; study of the effects of local and systemic inflammation induced by hypercholesterolemic diet in pre-clinical models of atherosclerosis.
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