Interaction of the Schiff base 2-hydroxyacetophenonepropylimine (happramH) with M(CO)₆, M=Cr or Mo under reduced pressure gave the dicarbonyl complex M(CO)₂(happramH)₂. The complex MoO(happram)₂ was isolated from the reaction of Mo(CO)₆ and happramH in air. Ru₃(CO)₁₂ and RuCl₃ reacted with the Schiff base bis-(2-hydroxyacetophenone)ethylenediimine (hapenH₂) to give Ru(CO)₂(hapenH₂) and [RuCl₂(hapenH2)]Cl. Elemental, spectroscopic and magnetic studies of the reported complexes revealed the proposed structures. The thermal properties of the complexes were investigated by thermogravimetric techniques. Cyclic voltammetry of the complexes showed tautomeric redox processes due to ligand-based reduction and metal-based oxidation.

Enaminonitrile pyridine derivative was used as a precursor for preparation of fourteen heterocyclic compounds using both conventional thermal and microwave techniques. Diverse organic reagents, such as chloroacetyl chloride, acetic anhydride, chloroacetic acid, carbon disulfide,p-toluene sulfonyl chloride, maleic anhydride, phthalic anhydride, were used. The chemical formulae and structures of isolated derivatives were obtained using different analytical and spectroscopic techniques such as IR,¹H-,¹³C-NMR as well as mass spectrometry. The spectroscopic analyses revealed diverse structure arrangements for the products. Molecular structure optimization of certain compounds were performed by the density functional theory (DFT/B3LYP) method and the basis set 6–31 G with double zeta plus polarization (d,p). The antimicrobial inhibition and the antioxidant activity of the reported compounds were screened. Compounds5,6,11and13exhibited the highest antibacterial inhibition, while compound8gave the highest scavenging activity (IC₅₀ 43.39 µg/ml) against the DPPH radical. Structure–activity relationship of the reported compounds were correlated with the data of antibacterial and the antioxidant activity. The global reactivity descriptors were also correlated with the biological properties of compounds. The molecular docking studies of reported compounds were investigated, and the analysis showed that the docked compounds have highly negative values for the functional binding scores. The binding interaction was found to be correlated with the substituent fragments of the compounds.