Dr. Sagnik Basuray

Electric induced dipoles of nanocolloids the size of the Debye length are shown to be one order stronger than predicted by the classical Maxwell-Wagner theory and its extensions. The difference is attributed to normal ion migration within the diffuse layer, and adsorption onto the Stern layer at the poles. The characteristic relaxation frequency (the crossover frequency for dielectrophoresis) is shown to be inversely proportional to the

R C

time of the diffuse layer capacitance and resistance, and has an anomalous

- 1

scaling with respect to the product of the Debye length and the particle size.

7 July 2009 in ACS Nano

Journal Article

Shear and AC Field Enhanced Carbon Nanotube Impedance Assay for Rapid, Sensitive, and Mismatch-Discriminating DNA Hybridization

Sagnik Basuray

Satyajyoti Senapati

Andrew Aijian

Andrew R. Mahon

Hsueh-Chia Chang

23 February 2010 in Lab on a Chip

Journal Article

A rapid field-use assay for mismatch number and location of hybridized DNAs

I-Fang Cheng

Satyajyoti Senapati

Xinguang Cheng

Sagnik Basuray

Hsueh-Chia Chang

Molecular dielectrophoresis (DEP) is employed to rapidly (<ms) trap ssDNA molecules in a flowing solution to a cusp-shaped nanocolloid assembly on a chip with a locally amplified AC electric field gradient. By tuning AC field frequency and DNA DEP mobility relative to its electrophoretic mobility due to electrostatic repulsion from like-charged nanocolloids, mismatch-specific binding of DNA molecules at the cusp is achieved by the converging flow, with a concentration factor about 6 orders of magnitude higher than the bulk, thus allowing fluorescent quantification of concentrated DNAs at the singularity in a generic buffer, at room temperature within a minute. Optimum flow rate and the corresponding hybridization rate change by nearly a factor of 2 with a single mismatch in the 26 base docking sequence and are also sensitive to the mismatch location. This dielectrophoresis and shear enhanced pico-molar sensitivity and SNP selectivity can hence be used for field-use DNA detection/identification.

About Me

Dr. Sagnik Basuray is an assistant professor at the Department of Chemical, Biological and Pharmaceutical Engineering at the College of Engineering. He completed his doctoral studies at the University of Notre Dame in the Department of Chemical and Bio-Molecular Engineering in 2011, where he won the best thesis award. Since 2012, he has been working as a postdoctoral fellow in the Department of Electrical and Computer Engineering, University of Missouri, at the Center for Micro/Nano Systems and Nanotechnology, in the area of materials science, nanotechnology and optics. Prior to his stint at Missouri, he was working as a Research Scientist at 454 Life Sciences, a Roche Company, building the next-generation semiconductor-based sequencing platform. His areas of expertise include developing chemical and biological sensors using nano/microfluidics and nanotechnology platforms; studying metal/dielectric/bio interfaces like SERS and Plasmonics; and electrodynamic and electrohydrodynamic simulations from bulk to nano. Dr. Sagnik Basuray has received the NSF Career Award and funding from multiple agencies. He currently holds five patents, which have translated into four startup companies.

Dr. Sagnik Basuray

Dr. Sagnik Basuray

Research Focus & Metrics

Academic Career Length

Publication Type Breakdown

Representative Publications

About Me