Dyslexia, attention deficit hyperactivity disorder (ADHD), and attention deficit disorder (ADD) show distinct clinical profiles that may include auditory and language-related impairments. Currently, an objective brain-based diagnosis of these developmental disorders is still unavailable. We investigated the neuro-auditory systems of dyslexic, ADHD, ADD, and age-matched control children (N=147) using neuroimaging, magnet-encephalography and psychoacoustics. All disorder subgroups exhibited an oversized left planum temporale and an abnormal interhemispheric asynchrony (10-40 ms) of the primary auditory evoked P1-response. Considering right auditory cortex morphology, bilateral P1 source waveform shapes, and auditory performance, the three disorder subgroups could be reliably differentiated with outstanding accuracies of 89-98%. We therefore for the first time provide differential biomarkers for a brain-based diagnosis of dyslexia, ADHD, and ADD. The method allowed not only a clear discrimination between two subtypes of attentional disorders (ADHD and ADD), a topic controversially discussed for decades in the scientific community, but also revealed the potential for objectively identifying comorbid cases. Noteworthy, in children playing a musical instrument, after three and a half years of training the observed interhemispheric asynchronies were reduced by about 2/3, thus suggesting a strong beneficial influence of music experience on brain development. These findings might have far-reaching implications for both research and practice and enable a profound understanding of the brain-related etiology, diagnosis, and musically based therapy of common auditory-related developmental disorders and learning disabilities.

Auditory perception is fundamental to human development and communication. However, no long-term studies have been performed on the plasticity of the auditory system as a function of musical training from childhood to adulthood. The long-term interplay between developmental and training-induced neuroplasticity of auditory processing is still unknown. We present results from AMseL (Audio and Neuroplasticity of Musical Learning), the first longitudinal study on the development of the human auditory system from primary school age until late adolescence. This 12-year project combined neurologic and behavioral methods including structural magnetic resonance imaging (MRI), magnetoencephalography (MEG), and auditory tests. A cohort of 112 typically developing participants (51 male, 61 female), classified as “musicians” (n = 66) and “nonmusicians” (n = 46), was tested at five measurement timepoints. We found substantial, stable differences in the morphology of auditory cortex (AC) between musicians and nonmusicians even at the earliest ages, suggesting that musical aptitude is manifested in macroscopic neuroanatomical characteristics. Maturational plasticity led to a continuous increase in white matter myelination and systematic changes of the auditory evoked P1-N1-P2 complex (decreasing latencies, synchronization effects between hemispheres, and amplitude changes) regardless of musical expertise. Musicians showed substantial training-related changes at the neurofunctional level, in particular more synchronized P1 responses and bilaterally larger P2 amplitudes. Musical training had a positive influence on elementary auditory perception (frequency, tone duration, onset ramp) and pattern recognition (rhythm, subjective pitch). The observed interplay between “nature” (stable biological dispositions and natural maturation) and “nurture” (learning-induced plasticity) is integrated into a novel neurodevelopmental model of the human auditory system.Significance StatementWe present results from AMseL (Audio and Neuroplasticity of Musical Learning), a 12-year longitudinal study on the development of the human auditory system from childhood to adulthood that combined structural magnetic resonance imaging (MRI), magnetoencephalography (MEG), and auditory discrimination and pattern recognition tests. A total of 66 musicians and 46 nonmusicians were tested at five timepoints. Substantial, stable differences in the morphology of auditory cortex (AC) were found between the two groups even at the earliest ages, suggesting that musical aptitude is manifested in macroscopic neuroanatomical characteristics. We also observed neuroplastic and perceptual changes with age and musical practice. This interplay between “nature” (stable biological dispositions and natural maturation) and “nurture” (learning-induced plasticity) is integrated into a novel neurodevelopmental model of the human auditory system.

Although there is strong evidence for the positive effects of musical training on auditory perception, processing, and training‐induced neuroplasticity, there is still little knowledge on the auditory and neurophysiological short‐term plasticity through listening training. In a sample of 37 adolescents (20 musicians and 17 nonmusicians) that was compared to a control group matched for age, gender, and musical experience, we conducted a 2‐week active listening training (AULOS: Active IndividUalized Listening OptimizationS). Using magnetoencephalography and psychoacoustic tests, the short‐term plasticity of auditory evoked fields and auditory skills were examined in a pre‐post design, adapted to the individual neuro‐auditory profiles. We found bilateral, but more pronounced plastic changes in the right auditory cortex. Moreover, we observed synchronization of the auditory evoked P1, N1, and P2 responses and threefold larger amplitudes of the late P2 response, similar to the reported effects of musical long‐term training. Auditory skills and thresholds benefited largely from the AULOS training. Remarkably, after training, the mean thresholds improved by 12 dB for bone conduction and by 3–4 dB for air conduction. Thus, our findings indicate a strong positive influence of active listening training on neural auditory processing and perception in adolescence, when the auditory system is still developing.

Research has shown that melody not only plays a crucial role in music but also in language acquisition processes. Evidence has been provided that melody helps in retrieving, remembering, and memorizing new language material, while relatively little is known about whether individuals who perceive speech as more melodic than others also benefit in the acquisition of oral languages. In this investigation, we wanted to show which impact the subjective melodic perception of speech has on the pronunciation of unfamiliar foreign languages. We tested 86 participants for how melodic they perceived five unfamiliar languages, for their ability to repeat and pronounce the respective five languages, for their musical abilities, and for their short-term memory (STM). The results revealed that 59 percent of the variance in the language pronunciation tasks could be explained by five predictors: the number of foreign languages spoken, short-term memory capacity, tonal aptitude, melodic singing ability, and how melodic the languages appeared to the participants. Group comparisons showed that individuals who perceived languages as more melodic performed significantly better in all language tasks than those who did not. However, even though we expected musical measures to be related to the melodic perception of foreign languages, we could only detect some correlations to rhythmical and tonal musical aptitude. Overall, the findings of this investigation add a new dimension to language research, which shows that individuals who perceive natural languages to be more melodic than others also retrieve and pronounce utterances more accurately.

Introduction: The present study aims to explore the extent to which auditory processing is reflected in the prefrontal cortex.Methods: Using magnetoencephalography (MEG), we investigated the chronology of primary and secondary auditory responses and associated co-activation in the orbitofrontal cortex in a large cohort of 162 participants of various ages. The sample consisted of 38 primary school children, 39 adolescents, 43 younger, and 42 middle-aged adults and was further divided into musically experienced participants and non-musicians by quantifying musical training and aptitude parameters.Results: We observed that the co-activation in the orbitofrontal cortex [Brodmann-Area 10 (BA10)] strongly depended on musical expertise but not on age. In the musically experienced groups, a systematic coincidence of peak latencies of the primary auditory P1 response and the co-activated response in the orbitofrontal cortex was observed in childhood at the onset of musical education. In marked contrast, in all non-musicians, the orbitofrontal co-activation occurred 25–40 ms later when compared with the P1 response. Musical practice and musical aptitude contributed equally to the observed activation and co-activation patterns in the auditory and orbitofrontal cortex, confirming the reciprocal, interrelated influence of nature, and nurture in the musical brain.Discussion: Based on the observed ageindependent differences in the chronology and lateralization of neurological responses, we suggest that orbitofrontal functions may contribute to musical learning at an early age.

Introduction: We present novel evidence that humans are capable of producing, perceiving, and cortically processing ultrasound (US), extending the recognized limits of human auditory function. This previously unacknowledged sensory ability was identified in an expert practitioner of the traditional Chinese health exercise “The Six Healing Sounds. Methods and results: High-resolution recordings demonstrated deliberate vocal emissions reaching up to 35 kHz, with nearly one third of the acoustic energy residing in the ultrasonic range. Magnetoencephalography (MEG) revealed a distinct cortical response to these US components, characterized by an additional early N1 peak at 87 ms in the left auditory cortex—about 20–25 ms earlier than the conventional N1 response. Importantly, this US-specific component was entirely absent in a large cohort of 202 vocalists comprising 23 Chinese and 172 European trained singers and furthermore 7 experienced ‘Healing Sound’ singers, none of whom produced or perceived vocal US. Beyond cortical physiology, psychophysical testing demonstrated a unique perceptual strategy in the qigong practitioner: at very high frequencies his pitch perception shifted from spectral to fundamental mode, enabling him to reconstruct coherent auditory objects even when ultrasonic components were only weakly present. Discussion: This finding may reflect an exceptional adaptive neuroplastic mechanism integrating US into auditory and regulatory brain networks, akin to functional reorganizations observed in professional musicians. Taken together, these results provide the first demonstration in a human case study of intentional ultrasonic vocalization combined with cortical US processing in a human. The discovery not only challenges the traditional definition of auditory limits but also opens promising perspectives for the role of US in internal communication, vegetative regulation, and clinical neuromodulation. Low-intensity US stimulation may thus represent a novel therapeutic avenue for auditory and neurological disorders.