Magnetic nanoparticles (MNPs) represent a class of small particles typically with diameters ranging from 1 to 100 nanometers. These nanoparticles are composed of magnetic materials such as iron, cobalt, nickel, or their alloys. The nanoscale size of MNPs gives them unique physicochemical (physical and chemical) properties not found in their bulk counterparts. Their versatile nature and unique magnetic behavior make them valuable in a wide range of scientific, medical, and technological fields. Over the past decade, there has been a significant surge in MNP-based applications spanning biomedical uses, environmental remediation, data storage, energy storage, and catalysis. Given their magnetic nature and small size, MNPs can be manipulated and guided using external magnetic fields. This characteristic is harnessed in biomedical applications, where these nanoparticles can be directed to specific targets in the body for imaging, drug delivery, or hyperthermia treatment. Herein, this roadmap offers an overview of the current status, challenges, and advancements in various facets of MNPs. It covers magnetic properties, synthesis, functionalization, characterization, and biomedical applications such as sample enrichment, bioassays, imaging, hyperthermia, neuromodulation, tissue engineering, and drug/gene delivery. However, as MNPs are increasingly explored for in vivo applications, concerns have emerged regarding their cytotoxicity, cellular uptake, and degradation, prompting attention from both researchers and clinicians. This roadmap aims to provide a comprehensive perspective on the evolving landscape of MNP research.

Superparamagnetic iron oxide nanoparticles (SPIONs) have emerged as cutting-edge materials, garnering increasing attention in recent years within the fields of chemical and biomedical engineering. This increasing interest is primarily attributed to the distinctive chemical and physical properties of SPIONs. Progress in nanotechnology and particle synthesis methodologies has facilitated the fabrication of SPIONs with precise control over parameters such as composition, size, shape, stability, and magnetic response. Notably, these functionalized materials exhibit a remarkable surface-area-to-volume ratio, biocompatibility, and, most importantly, they can be effectively manipulated using external magnetic fields. Due to these exceptional properties, SPIONs have found widespread utility in the medical field for targeted drug delivery and cell separation, as well as in the chemical engineering field, particularly in wastewater treatment. Magnetic separation techniques driven by magnetophoresis have proven to be highly efficient, encompassing both high-gradient magnetic separation (HGMS) and low-gradient magnetic separation (LGMS). This review aims to provide an in-depth exploration of magnetic field gradient separation techniques, alongside a comprehensive discussion of the applications of SPIONs in the context of drug delivery, cell separation, and environmental remediation.

Purpose: The benefits of adopting lean manufacturing for leveraging corporate sustainability have been highlighted in the literature. However, these studies have neglected the social side of sustainability compared with the attention given to the environmental aspects. Addressing this gap, this paper aims to investigate the influence of lean practices on the dimensions of employee social sustainability (ESS), which enabled the identification of the most critical practices. Design/methodology/approach: This paper conducted an exploratory study in two phases: first, seeking evidence in the literature, and second, applying the analytic hierarchy process (AHP) to connect ESS to lean practices based on expert opinion. Findings: From the literature review, this paper found linkages between eight lean manufacturing practices and four dimensions of ESS. Based on evidence from the literature, the authors designed and applied an AHP model to set priorities among lean practices and social dimensions. Therefore, “health and safety” was evaluated as the most critical social dimension, and 5S was considered the most influential lean practice on ESS. Originality/value: This study contributed to introducing the perspective of lean manufacturing practices as enablers of ESS. Notably, it pointed out which specific practices should be prioritized in the lean implementation process with social sustainability purposes. In addition, it identified relationships not reported in the literature, raising questions for further investigation.