Tumor metastasis is the principal cause of cancer-related death. Similarly, drug resistance is the major obstacle to effective cancer therapy, driving high relapse and mortality rates. I am studying how epithelial-mesenchymal plasticity drives metastasis in hepatocellular carcinoma (HCC) with the aim of identifying novel pharmacological targets to block metastasis. Similarly, I am studying how kinome rewiring drives chemoresistance; my goal is to devise kinase inhibitor/chemotherapy combinations that prevent HCC chemo-adaption.