Cancer remains a major health burden in Lithuania, emphasizing the importance of effective undergraduate oncology education. This paper describes the structure and key features of the integrated oncology curriculum at the Lithuanian University of Health Sciences (LSMU). Oncology teaching is embedded within a six-year medical programme, combining early exposure through biomedical sciences with focused clinical training in a mandatory Year IV Hematology and Oncology module. Teaching methods include lectures, small-group seminars, and supervised ward-based learning, with a strong emphasis on case-based discussion and clinical reasoning. Students are introduced to principles of cancer diagnosis, staging, treatment, and multidisciplinary decision-making. Simulation and practical skills training further support clinical competence. Assessment includes written examinations and clinical case assignments, aligned with programme-level evaluations such as OSCE. Teaching is delivered in a multidisciplinary academic environment with structured quality assurance and continuous student feedback. This model provides a clinically grounded and integrated approach to cancer education, ensuring continuity from undergraduate medical education to postgraduate specialist training. Expanding hands-on clinical exposure, strengthening communication training, and incorporating emerging technologies such as artificial intelligence may further enhance the curriculum.

Background: Toxic epidermal necrolysis (TEN) is a rare but life-threatening complication that may occur in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT), particularly in the context of extensive drug exposure. In this population, TEN can closely resemble severe acute graft-versus-host disease (GVHD), making diagnosis and management challenging. Case presentation: We report the clinical course of an allo-HSCT recipient who developed a rapidly progressive skin rash early after transplantation, and we analyzed the clinical features, histopathology, treatment and outcome. Results: The patient developed rapidly progressive epidermal detachment with severe oral, ocular, and genital mucosal involvement shortly after exposure to trimethoprim/sulfamethoxazole (TMP-SMX). Disease severity was reflected by a SCORTEN score of 5, corresponding to a very high predicted mortality risk. The clinical picture raised concern for both TEN and severe acute GVHD, while histopathological findings favored TEN but were not definitive. Management included systemic corticosteroids, intravenous immunoglobulin, ruxolitinib, and intensive supportive care. The patient gradually re-epithelialized and recovered without long-term sequelae. Conclusions: This case underscores the diagnostic difficulty of distinguishing TEN from severe acute GVHD in the early post-transplant period. Careful assessment of drug exposure, clinical evolution, and multidisciplinary evaluation are essential to guide timely and appropriate management.