Most cathode materials for Li-ion batteries exhibit a low electronic conductivity. Therefore, a considerable amount of conductive additives is added during electrode production. A mixed phase of carbon and binder provides a 3D network for electron transport and at the same time improves the mechanical stability of the electrodes. However, this so-called carbon binder domain (CBD) hinders the transport of lithium ions through the electrolyte and reduces the specific energy of the cells. Therefore, the CBD content is an important design parameter for optimal battery performance. In the present study, stochastic 3D microstructure modeling, microstructure characterization, conductivity simulations as well as microstructure-resolved electrochemical simulations are performed to identify the influence of the CBD content and its spatial distribution on electrode performance. The electrochemical simulations on virtual, but realistic, electrode microstructures with different active material content and particle size distributions provide insights to limiting transport mechanisms and optimal electrode configurations. Furthermore, we use the results of both the microstructure characterization and electrochemical simulations to deduce extensions of homogenized cell models providing improved predictions of cell performance at low CBD contents relevant for high energy density batteries.