In this paper, a novel high-gain DC-DC boost converter with reduced component count is proposed. The converter that is proposed in this paper provides high DC voltage gain, while keeping the overall component count significantly lower in comparison to some similar high voltage gain DC-DC converters presented recently. The proposed converter uses only one power switch, two inductors, two capacitors, and three didoes to achieve high-voltage gain, without a significant compromise on the efficiency. In addition, the proposed design uses small passive component sizes compared to other similar designs of the same power rating. Due to the reduced component count, and hence the small physical size, the proposed converter will find applications in several practical domains, ranging from industrial control embedded systems to the DC transmission bus bars in fully electrical vehicles and renewable energy distribution grids. A 250 Watts prototype of this newly proposed DC-DC boost converter was implemented and simulated using the PSIM simulation tool. The promising simulation results proved the reliable performance of the proposed DC-DC boost converter design.