Vahid Khalaj

Dr. Vahid Khalaj

orcid
SR Research Scientist at University of Texas Health Center, ...

Biography

My work is in molecular biology and biotechnology, with a focus on designing and manipulating biological systems for targeted therapies and drug delivery. Over time, I have moved toward questions that sit at the intersection of recombinant protein engineering, cancer biology, and nanotechnology. I am especially interested in platforms that define components, particularly a specific ligand, a specific carrier, and a well‑characterized target in the tumor or its microenvironment. My current interest is drug delivery using bacterial Outer Membrane Vesicles (OMVs). I view OMVs as a flexible biological platform. Because they are naturally produced vesicles, they can be engineered at the level of the bacterial strain so that specific proteins or ligands appear on their surface. I am interested in surface-engineered OMVs that carry tumor-targeting moieties, such as affibodies, fusogenic peptides, or receptor-binding ligands (e.g., octreotide-based ligands for SSTR2). The aim is to help these vesicles find and bind specific tumor or stromal cells, deliver a defined payload to them, and use this approach to actively modify the tumor microenvironment, especially in immunocold tumors, so that it becomes more permissive to effective anti-tumor immune responses and other therapies.

Affiliations

No affiliation has been shared yet.

Honors and Awards

No honors or awards have been shared yet.

Experience

No experience has been shared yet.