My research domain focuses on the digitalization and intelligent upgrading of smart manufacturing systems, primarily encompassing three key directions: Cyber-Physical Systems (CPS), Multi-Agent Manufacturing Systems (MAS), and Digital Twin (DT). Through the convergence of advanced technologies, this work aims to achieve autonomous coordination and dynamic optimization across the entire manufacturing workflow. The research establishes a systematic framework that integrates real-time perception, distributed decision-making, and predictive simulation capabilities, driving transformative innovations in agile response, resilient operation, and sustainable evolution of next-generation intelligent manufacturing systems.